A continuación, se presentan todos los manuscritos escritos por el Harvard Aging Brain Study del 2009 al 2019. Última actualización: diciembre 2019

2019

Biddle KD, d’Oleire Uquillas F, Jacobs HIL, Zide B, Kirn DR, Rentz DM, Johnson KA, Sperling RA, Donovan NJ. Social Engagement and Amyloid-β-Related Cognitive Decline in Cognitively Normal Older Adults. American Journal of Geriatric Psychiatry. 2019 May 10. pii: S1064-7481(19)30360-4. doi: 10.1016/j.jagp.2019.05.005. [Epub ahead of print] PubMed PMID: 31248770.

Buckley RF, Mormino EC, Chhatwal J, Schultz AP, Rabin JS, Rentz DM, Acar D, Properzi MJ, Dumurgier J, Jacobs H, Gomez-Isla T, Johnson KA, Sperling RA, Hanseeuw BJ; Associations between baseline amyloid, sex, and APOE on subsequent tau accumulation in cerebrospinal fluid. Alzheimer’s Disease Neuroimaging Initiative. Neurobiology of Aging. 2019 Mar 7;78:178-185. doi: 10.1016/j.neurobiolaging.2019.02.019. [Epub ahead of print] PMID: 30947113; PMC In Process.

Buckley RF, Mormino EC, Rabin JS, Hohman TJ, Landau S, Hanseeuw BJ, Jacobs HIL, Papp KV, Amariglio RE, Properzi MJ, Schultz AP, Kirn D, Scott MR, Hedden T, Farrell M, Price J, Chhatwal J, Rentz DM, Villemagne VL, Johnson KA, Sperling RA. Sex Differences in the Association of Global Amyloid and Regional Tau Deposition Measured by Positron Emission Tomography in Clinically Normal Older Adults. JAMA Neurol. 2019 Feb 4. doi: 10.1001/jamaneurol.2018.4693. [Epub ahead of print] PubMed PMID: 30715078; NIHMSID: NIHMS1029661. PMC In Process.

Chen Z, Mengel D, Keshavan A, Rissman RA, Billinton A, Perkinton M, Percival-Alwyn J, Schultz A, Properzi M, Johnson K, Selkoe DJ, Sperling RA, Patel P, Zetterberg H, Galasko D, Schott JM, Walsh DM. Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer’s disease. Alzheimer’s & Dementia. 2019 March;15(3);487-496. PubMed PMID: 30419228; PubMed Central PMCID: PMC6476313.

d’Oleire Uquillas F, Jacobs HIL, Schultz AP, Hanseeuw BJ, Buckley RF, Sepulcre J, Pascual-Leone A, Donovan NJ, Johnson KA, Sperling RA, Vannini P. Functional and Pathological Correlates of Judgments of Learning in Cognitively Unimpaired Older Adults. Cereb Cortex. 2019 Nov 6;. doi: 10.1093/cercor/bhz217. [Epub ahead of print] PubMed PMID: 31696223.

Gatchel JR, Rabin JS, Buckley RF, Locascio JJ, Quiroz YT, Yang HS, Vannini P,  Amariglio RE, Rentz DM, Properzi M, Donovan NJ, Blacker D, Johnson KA, Sperling RA, Marshall GA; Harvard Aging Brain Study. Longitudinal Association of Depression Symptoms With Cognition and Cortical Amyloid Among Community-Dwelling Older Adults. JAMA Netw Open. 2019 Aug 2;2(8):e198964. doi: 10.1001/jamanetworkopen.2019.8964. PubMed PMID: 31397865.

Hanseeuw BJ, Scott MR, Sikkes SAM, Properzi M, Gatchel JR, Salmon E, Marshall GA, Vannini P. Evolution of anosognosia in alzheimer’s disease and its relationship to amyloid. Ann Neurol. 2019 Nov 21;. doi: 10.1002/ana.25649. [Epub ahead of print] PubMed PMID: 31750553; NIHMSID:NIHMS1066473.

Hanseeuw BJ, Betensky RA, Jacobs HIL, Schultz AP, Sepulcre J, Becker JA, Cosio DMO, Farrell M, Quiroz YT, Mormino EC, Buckley RF, Papp KV, Amariglio RA, Dewachter I, Ivanoiu A, Huijbers W, Hedden T, Marshall GA, Chhatwal JP, Rentz DM, Sperling RA, Johnson K. Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease: A Longitudinal Study. JAMA Neurol. 2019 Jun 3. doi: 10.1001/jamaneurol.2019.1424. [Epub ahead of print] PubMed PMID: 31157827; PubMed Central PMCID: PMC6547132.

Hanseeuw BJ, Lopera F, Sperling RA, Norton DJ, Guzman-Velez E, Baena A, Pardilla-Delgado E, Schultz AP, Gatchel J, Jin D, Chen K, Reiman EM, Johnson KA, Quiroz YT. Striatal amyloid is associated with tauopathy and memory decline in familial Alzheimer’s disease. Alzheimers Research Therapy. 2019 Feb 4;11(1):17. doi:10.1186/s13195-019-0468-1. PubMed PMID: 30717814; PubMed Central PMCID: PMC6362587.

Huijbers W, Schultz AP, Papp KV, LaPoint MR, Hanseeuw B, Chhatwal JP, Hedden T, Johnson KA, Sperling RA. Tau Accumulation in Clinically Normal Older Adults Is Associated with Hippocampal Hyperactivity. The Journal of Neuroscience. 2019 January 16;39(3):548-556. PubMed PMID: 30482786; PubMed Central PMCID: PMC6335746.

Lois C, Gonzalez I, Johnson KA, Price JC. PET imaging of tau protein targets: a methodology perspective. Brain Imaging and Behavior. 2019 April;13(2):333-344. PubMed PMID: 29497982; PubMed Central PMCID: PMC6119534.

Marshall GA, Aghjayan SL, Dekhtyar M, Locascio JJ, Jethwani K, Amariglio RE, Czaja SJ, Loewenstein DA, Johnson KA, Sperling RA, Rentz DM. Measuring instrumental activities of daily living in non-demented elderly: a comparison of the new performance-based Harvard Automated Phone Task with other functional assessments. Alzheimers Research Therapy. 2019 Jan 10;11(1):4. doi: 10.1186/s13195-018-0464-x. PMID: 30630529; PubMed Central PMCID: PMC6329044.

Marshall GA, Gatchel JR, Donovan NJ, Muniz MC, Schultz AP, Becker JA, Chhatwal JP, Hanseeuw BJ, Papp KV, Amariglio RE, Rentz DM, Sperling RA, Johnson KA. Regional Tau Correlates of Instrumental Activities of Daily Living and Apathy in Mild Cognitive Impairment and Alzheimer’s Disease Dementia. J Alzheimers Disease. 2019;67(2):757-768. doi: 10.3233/JAD-170578. PubMed PMID: 30689584; PubMed Central PMCID: PMC6352915.

Properzi MJ, Buckley RF, Chhatwal JP, Donohue MC, Lois C, Mormino EC, Johnson KA, Sperling RA, Schultz AP. Nonlinear Distributional Mapping (NoDiM) for harmonization across amyloid-PET radiotracers. NeuroImage. 2019 February 1;1 86:446-454. PubMed PMID: 30458305; PubMed Central PMCID: PMC6338495.

Rabin JS, Klein H, Kirn D, Schultz A, Yang HS, Hampton O, Jiang S, Buckley R, Viswanathan  A, Hedden T, Pruzin J, Yau WY, Guzman-Velez E, Quiroz Y, Properzi M, Marshall GA, Rentz DM, Johnson KA, Sperling RA, Jasmeer P. Chhatwal. Physical activity moderates the association of β-amyloid burden on longitudinal cognition and neurodegeneration in clinically-normal older adults. Annals of Neurology (In press). PMC In Process.

Rabin JS, Perea RD, Buckley RF, Neal TE, Buckner RL, Johnson KA, Sperling RA, Hedden T.  Global White Matter Diffusion Characteristics Predict Longitudinal Cognitive Change Independently of Amyloid Status in Clinically Normal Older Adults. Cerebral Cortex (New York, N.Y. 1991). 2019 Mar 1;29(3):1251-1262. PubMed PMID: 29425267; PubMed Central PMCID: PMC6499008.

Rabin JS, Yang HS, Schultz AP, Hanseeuw BJ, Hedden T, Viswanathan A, Gatchel JR, Marshall GA, Kilpatrick E, Klein H, Rao V, Buckley RF, Yau WW, Kirn DR, Rentz DM, Johnson KA, Sperling RA, Chhatwal JP. Vascular Risk and β-Amyloid Are Synergistically Associated with Cortical Tau. Annals of Neurology 2019 February;85(2):272-279. PubMed PMID: 30565287; PubMed Central PMCID: PMC6351182.

Rabin, JS, Perea, R, Buckley, RF, Johnson, KA, Sperling, RA, Hedden, T. Synergism between fornix microstructure and beta-amyloid accelerates memory decline in clinically normal older adults. Neurobiology of Aging. (In press). PMC In Process.

Sperling RA, Mormino EC, Schultz AP, Betensky RA, Papp KV, Amariglio RE, Hanseeuw BJ,  Buckley R, Chhatwal J, Hedden T, Marshall GA, Quiroz YT, Donovan NJ, Jackson J, Gatchel JR, Rabin JS, Jacobs H, Yang HS, Properzi M, Kirn DR, Rentz DM, Johnson KA. The impact of amyloid-beta and tau on prospective cognitive decline in older individuals. Annals of Neurology. 2019 February;85(2):181-193. PubMed PMID:30549303; PubMed Central PMCID: PMC6402593.

Vannini P, Uquillas FD, Jacobs HIL, Sepulcre J, Gatchel J, Amariglio RE, Hanseeuw B, Papp KV, Hedden T, Rentz DM, Pascual-Leone A, Johnson KA, Sperling RA. Decreased meta-memory is associated with early tauopathy in cognitively unimpaired older adults. Neuroimage Clin. 2019;24:102097. doi: 10.1016/j.nicl.2019.102097. Epub 2019 Nov 18. PubMed PMID: 31795044; PubMed Central PMCID: PMC6879982.

Yang HS, Chhatwal JP, Xu J, White CC, Hanseeuw B, Rabin JS, Papp KV, Buckley RF, Schultz   AP, Properzi MJ, Gatchel JR, Amariglio RE, Donovan NJ, Mormino EC, Hedden T, Marshall GA, Rentz DM, Johnson KA, De Jager PL, Sperling RA. J. An UNC5C Allele Predicts Cognitive Decline and Hippocampal Atrophy in Clinically Normal Older Adults. J. Alzheimers Disease. 2019;68(3):1161-1170. doi: 10.3233/JAD-180788. [Epub ahead of print] PMID: 30883345; NIHMSID: NIHMS1029671. PMC In Process.

2018

Amariglio RE, Buckley RF, Mormino EC, Marshall GA, Johnson KA, Rentz DM, Sperling RA. Amyloid-associated increases in longitudinal report of subjective cognitive complaints. Alzheimer’s Dementia (New York, N. Y.). 2018 September 6;4:444-449. PubMed PMID: 30258973; PubMed Central PMCID: PMC6153378.

Buckley RF, Mormino EC, Amariglio RE, Properzi MJ, Rabin JS, Lim YY, Papp KV, Jacobs HIL, Burnham S, Hanseeuw BJ, Doré V, Dobson A, Masters CL, Waller M, Rowe CC, Maruff P, Donohue MC, Rentz DM, Kirn D, Hedden T, Chhatwal J, Schultz AP, Johnson KA, Villemagne VL, Sperling RA. Sex, amyloid, and APOE ε4 and risk of cognitive decline in preclinical Alzheimer’s disease: Findings from three well- characterized cohorts. Alzheimer’s Dementia. 2018 September;14(9):1193-1203. PubMed PMID: 29803541; PubMed Central PMCID: PMC6131023.

Chhatwal JP, Schultz AP, Johnson KA, Hedden T, Jaimes S, Benzinger TLS, Jack C Jr, Ances BM, Ringman JM, Marcus DS, Ghetti B, Farlow MR, Danek A, Levin J, Yakushev I, Laske C, Koeppe RA, Galasko DR, Xiong C, Masters CL, Schofield PR, Kinnunen KM, Salloway S, Martins RN, McDade E, Cairns NJ, Buckles VD, Morris JC, Bateman R, Sperling RA. Preferential degradation of cognitive networks differentiates Alzheimer’s disease from ageing. Brain a Journal of Neurology. 2018 May 1;141(5):1486-1500. PubMed PMID: 29522171; PubMed Central PMCID: PMC5917745.

Chiou SH, Austin MD, Qian J, Betensky RA. Transformation model estimation of survival under dependent truncation and independent censoring. Statistical Methods in Medical Research. 2018 December 13:1-14;962280218817573. PubMed PMID: 30543153; NIHMSID: NIHMS1029640. PMC In Process.

Chiou SH, Qian J, Mormino E, Betensky RA; Alzheimer’s Disease Neuroimaging Initiative; Australian Imaging Biomarkers Lifestyle Flagship Study of Aging; Harvard Aging Brain Study. Permutation Tests for General Dependent Truncation. Comput Stat Data Anal. 2018 Dec; 128:308-324. doi: 10.1016/j.csda.2018.07.012. Epub 2018 Jul 29. PubMed PMID: 30613119; PubMed Central PMCID: PMC6317381.

d’Oleire Uquillas F, Jacobs HIL, Biddle KD, Properzi M, Hanseeuw B, Schultz AP, Rentz DM, Johnson KA, Sperling RA, Donovan NJ. Regional tau pathology and loneliness in cognitively normal older adults. Translational Psychiatry. 2018 December 18;8(1):282. PubMed PMID: 30563962; PubMed Central PMCID: PMC6299114.

d’Oleire Uquillas F, Jacobs HIL, Hanseeuw B, Marshall GA, Properzi M, Schultz AP, LaPoint MR, Johnson KA, Sperling RA, Vannini P. Interactive versus additive relationships between regional cortical thinning and amyloid burden in predicting clinical decline in mild AD and MCI individuals. Neuroimage Clin. 2018;17:388-396. doi: 10.1016/j.nicl.2017.10.034. eCollection 2018. PubMed PMID: 29159051; PubMed Central PMCID: PMC5683806.

Donovan NJ, Locascio JJ, Marshall GA, Gatchel J, Hanseeuw BJ, Rentz DM, Johnson KA, Sperling RA. Longitudinal Association of Amyloid Beta and Anxious-Depressive Symptoms in Cognitively Normal Older Adults. The American Journal of Psychiatry. 2018 June 1;175(6):530-537. PubMed PMID: 29325447; PubMed Central PMCID: PMC5988933.

Hanseeuw BJ, Betensky RA, Mormino EC, Schultz AP, Sepulcre J, Becker JA, Jacobs HIL, Buckley RF, LaPoint MR, Vannini P, Donovan NJ, Chhatwal JP, Marshall GA, Papp KV, Amariglio RE, Rentz DM, Sperling RA, Johnson KA. PET staging of amyloidosis using striatum. Alzheimer’s & Dementia. 2018 October;14(10):1281-1292. PubMed PMID: 29792874; PubMed Central PMCID: PMC6219621.

Hanseeuw BJ, Jonas V, Jackson J, Betensky RA, Rentz DM, Johnson KA, Sperling RA, Donovan NJ. Association of anxiety with subcortical amyloidosis in cognitively normal older adults. Molecular Psychiatry. 2018 August 16;1-9. PubMed PMID: 30116029; PubMed Central PMCID: PMC6377864.

Jacobs HIL, Hedden T, Schultz AP, Sepulcre J, Perea RD, Amariglio RE, Papp KV, Rentz DM, Sperling RA, Johnson KA. Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals. Nature Neuroscience. 2018 March;21(3):424-431. PubMed PMID: 29403032; PubMed Central PMCID: PMC5857215.

Lee C, Betensky RA. Time-to-event data with time-varying biomarkers measured only at study entry, with applications to Alzheimer’s disease. Statistics in Medicine. 2018 Mar 15;37(6):914-932. PubMed PMID: 29266591; PubMed Central PMCID: PMC5801265.

Lee CM, Jacobs HIL, Marquié M, Becker JA, Andrea NV, Jin DS, Schultz AP, Frosch MP, Gómez-Isla T, Sperling RA, Johnson KA. 18F-Flortaucipir Binding in Choroid Plexus: Related to Race and Hippocampus Signal. Journal of Alzheimer’s Disease. 2018;62(4):1691-1702. PubMed PMID: 29614677; PubMed Central PMCID: PMC5957532.

Munro CE, Donovan NJ, Amariglio RE, Papp KV, Marshall GA, Rentz DM, Pascual-Leone A, Sperling RA, Locascio JJ, Vannini P. The Impact of Awareness of and Concern About Memory Performance on the Prediction of Progression From Mild Cognitive Impairment to Alzheimer Disease Dementia. Am J Geriatr Psychiatry. 2018 Aug;26(8):896-904. doi: 10.1016/j.jagp.2018.04.008. Epub 2018 May 3. PubMed PMID: 29866588; PubMed Central PMCID: PMC6959130.

Orlovsky I, Huijbers W, Hanseeuw BJ, Mormino EC, Hedden T, Buckley RF, LaPoint M, Rabin JS, Rentz DM, Johnson KA, Sperling RA, Papp KV. The relationship between recall of recently versus remotely encoded famous faces and amyloidosis in clinically normal older adults. Alzheimer’s & Dementia (Amsterdam, Netherlands).2018;10:121-129. PubMed PMID: 29780861; PubMed Central PMCID: PMC5956796.

Perea RD, Rabin JS, Fujiyoshi MG, Neal TE, Smith EE, Van Dijk KRA, Hedden T. Connectome-derived diffusion characteristics of the fornix in Alzheimer’s disease. NeuroImage. Clinical. 2018 April 27; 19:331-342. PubMed PMID: 30013916; PubMed Central PMCID: PMC6044183.

Qian J, Chiou SH, Maye JE, Atem F, Johnson KA, Betensky RA. Threshold regression to accommodate a censored covariate. Biometrics. 2018 Dec;74(4):1261-1270. PubMed PMID: 29933515; PubMed Central PMCID: PMC6321791.

Quiroz YT, Sperling RA, Norton DJ, Baena A, Arboleda-Velasquez JF, Cosio D, Schultz A, Lapoint M, Guzman-Velez E, Miller JB, Kim LA, Chen K, Tariot PN, Lopera F, Reiman EM, Johnson KA. Association Between Amyloid and Tau Accumulation in Young Adults With Autosomal Dominant Alzheimer Disease. JAMA Neurology. 2018 May 1;75(5):548-556. PubMed PMID: 29435558; PubMed Central PMCID: PMC5885174.

Rabin JS, Schultz AP, Hedden T, Viswanathan A, Marshall GA, Kilpatrick E, Klein H, Buckley RF, Yang HS, Properzi M, Rao V, Kirn DR, Papp KV, Rentz DM, Johnson KA, Sperling RA, Chhatwal JP. Interactive Associations of Vascular Risk and β-Amyloid Burden with Cognitive Decline in Clinically Normal Elderly Individuals: Findings from the Harvard Aging Brain Study. JAMA Neurology. 2018 September 1;75(9):1124-1131. PubMed PMID: 29799986; PubMed Central PMCID: PMC6143121.

Rieckmann A, Johnson KA, Sperling RA, Buckner RL, Hedden T. Dedifferentiation of   caudate functional connectivity and striatal dopamine transporter density predict memory change in normal aging. Proceedings of the National Academy of Sciences of the United States of America. 2018 October 2;115(40):10160-10165. PubMed PMID: 30224467; PubMed Central PMCID: PMC6176586.

Sepulcre J, Grothe MJ, d’Oleire Uquillas F, Ortiz-Terán L, Diez I, Yang HS, Jacobs HIL, Hanseeuw BJ, Li Q, El-Fakhri G, Sperling RA, Johnson KA. Neurogenetic contributions to amyloid beta and tau spreading in the human cortex. Nature Medicine. 2018 December;24(12):1910-1918. PubMed PMID: 30374196; NIHMSID: NIHMS1027665. PMC In Process.

Zott B, Busche MA, Sperling RA, Konnerth A. What Happens with the Circuit in Alzheimer’s Disease in Mice and Humans? Annual Review Neuroscience. 2018 Jul 8;41:277-297. 10.1146/annurev-neuro-080317-061725 PMID: 29986165. NIHMSID: NIHMS1029649. PMC In Process.

2017

Aghjayan SL, Buckley RF, Vannini P, Rentz DM, Jackson JD, Sperling RA, Johnson KA, Amariglio RE. The influence of demographic factors on subjective cognitive concerns and beta-amyloid. International Psychogeriatrics. 2017 Apr;29(4):645-652. PubMed PMID: 27724996; PubMed Central PMCID: PMC5361739.

Atem FD, Qian, J, Maye JE, Johnson KA, Betensky RA, Linear Regression with a Randomly Censored Covariate: Application to an Alzheimer’s Study. Journal of the Royal Statistical Society. SeriesC, Applied statistics. 2017;66(2):313-328. doi:10.1111/rssc.12164. Epub 2016 Jun 27. PMID: 28239197; PubMed Central PMCID: PMC5319605.

Buckley RF, Hanseeuw B, Schultz AP, Vannini P, Aghjayan SL, Properzi MJ, Jackson JD, Mormino EC, Rentz DM, Sperling RA, Johnson KA, Amariglio RE. Region-Specific Association of Subjective Cognitive Decline with Tauopathy Independent of Global β- Amyloid Burden. JAMA Neurology. 2017 December 1;74(12):1455-1463. PubMed PMID: 28973551; PubMed Central PMCID: PMC5774633.

Buckley RF, Schultz AP, Hedden T, Papp KV, Hanseeuw BJ, Marshall G, Sepulcre J, Smith EE, Rentz DM, Johnson KA, Sperling RA, Chhatwal JP. Functional network integrity presages cognitive decline in preclinical Alzheimer disease. Neurology. 2017 July 4;89(1):29-37. PubMed PMID: 28592457; PubMed Central PMCID: PMC5496516.

Buckley RF, Sparks KP, Papp KV, Dekhtyar M, Martin C, Burnham S, Sperling RA, Rentz DM. Computerized Cognitive Testing for Use in Clinical Trials: A Comparison of the NIH Toolbox and Cogstate C3 Batteries. The Journal of Prevention of Alzheimer Disease. 2017;4(1):3-11. PubMed PMID: 29188853; PubMed Central PMCID: PMC5726304.

Dagley A, LaPoint M, Huijbers W, Hedden T, McLaren DG, Chatwal JP, Papp KV, Amariglio RE, Blacker D, Rentz DM, Johnson KA, Sperling RA, Schultz AP. Harvard Aging Brain Study: Dataset and accessibility. Neuroimage. 2017 Jan;144(Pt B):255-258; PubMed PMID: 25843019; PubMed Central PMCID: PMC4592689.

Dekhtyar M, Papp KV, Buckley R, Jacobs HIL, Schultz AP, Johnson KA, Sperling RA, Rentz DM. Neuroimaging markers associated with maintenance of optimal memory performance in late-life. Neuropsychologia. 2017 June;100:164-170. PubMed PMID: 28472627; PubMed Central PMCID: PMC5522601.

Donovan NJ, Wu Q, Rentz DM, Sperling RA, Marshall GA, Glymour MM. Loneliness, depression and cognitive function in older U.S. adults. International Journal of Geriatric Psychiatry. 2017 May;32(5):564-573. PubMed PMID: 27162047; PubMed Central PMCID: PMC5102822.

Dumurgier J, Hanseeuw BJ, Hatling FB, Judge KA, Schultz AP, Chhatwal JP, Blacker D, Sperling RA, Johnson KA, Hyman BT, Gómez-Isla T. Alzheimer’s Disease Biomarkers and Future Decline in Cognitive Normal Older Adults. Journal of Alzheimer’s Disease: JAD. 2017;60(4):1451-1459. PubMed PMID: 29036824; PubMed Central PMCID: PMC5773095.

Gatchel JR, Donovan NJ, Locascio JJ, Schultz AP, Becker JA, Chhatwal J, Papp KV, Amariglio RE, Rentz DM, Blacker D, Sperling RA, Johnson KA, Marshall GA. Depressive Symptoms and Tau Accumulation in the Inferior Temporal Lobe and Entorhinal Cortex in Cognitively Normal Older Adults: A Pilot Study. Journal of Alzheimer’s Disease: JAD. 2017;59(3):975-985. PubMed PMID: 28697559; PubMed Central PMCID: PMC5577564.

Hanseeuw BJ, Betensky RA, Schultz AP, Papp KV, Mormino EC, Sepulcre J, Bark JS, Cosio DM, LaPoint M, Chhatwal JP, Rentz DM, Sperling RA, Johnson KA. Fluorodeoxyglucose metabolism associated with tau-amyloid interaction predicts memory decline. Annals of Neurology. 2017 April;81(4):583-596. PubMed PMID: 28253546; PubMed Central PMCID: PMC5404378.

Huijbers W, Papp KV, LaPoint M, Wigman SE, Dagley A, Hedden T, Rentz DM, Schultz AP, Sperling RA. Age-Related Increases in Tip-of-the-tongue are Distinct from Decreases in Remembering Names: A Functional MRI Study. Cerebral Cortex (New York, N.Y.1991). 2017 Sep 1;27(9):4339-4349. PubMed PMID: 27578492; PubMed Central PMCID: PMC6074848.

LaPoint MR, Chhatwal JP, Sepulcre J, Johnson KA, Sperling RA, Schultz AP. The association between tau PET and retrospective cortical thinning in clinically normal elderly. NeuroImage. 2017 August 15;157:612-622. PubMed PMID: 28545932; PubMed Central PMCID: PMC5772972.

Marquié M, Normandin MD, Meltzer AC, Siao Tick Chong M, Andrea NV, Antón- Fernández A, Klunk WE, Mathis CA, Ikonomovic MD, Debnath M, Bien EA, Vanderburg CR, Costantino I, Makaretz S, DeVos SL, Oakley DH, Gomperts SN, Growdon JH, Domoto-Reilly K, Lucente D, Dickerson BC, Frosch MP, Hyman BT, Johnson KA, Gómez-Isla T. Pathological correlations of [F-18]-AV-1451 imaging in non-alzheimer tauopathies. Annals of Neurology. 2017 January;81(1):117-128. PubMed PMID: 27997036; PubMed Central PMCID: PMC5319193.

Marquié M, Siao Tick Chong M, Antón-Fernández A, Verwer EE, Sáez-Calveras N, Meltzer AC, Ramanan P, Amaral AC, Gonzalez J, Normandin MD, Frosch MP, Gómez- Isla T. [F-18]-AV-1451 binding correlates with postmortem neurofibrillary tangle Braak staging. Acta Neuropathologica. 2017 October;134(4):619-628. PubMed PMID: 28612291; PubMed Central PMCID: PMC5772971.

Marshall GA, Aghjayan SL, Dekhtyar M, Locascio JJ, Jethwani K, Amariglio RE, Johnson KA, Sperling RA, Rentz DM. Activities of daily living measured by the Harvard Automated Phone Task track with cognitive decline over time in non-demented elderly. The Journal of Prevention of Alzheimer’s Disease. 2017;4(2):81-86. PubMed PMID: 29124043; PubMed Central PMCID: PMC5675571.

McDonough IM, Beta-amyloid and Cortical Thickness Reveal Racial Disparities in Preclinical Alzheimer’s Disease. NeuroImage Clinical 2017 Sep 21;16:659-667. doi: 10.1016/j.nicl.2017.09.014. PubMed PMID: 29868439; PubMed Central PMCID: PMC5984571.

Molinuevo JL, Rabin LA, Amariglio R, Buckley R, Dubois B, Ellis KA, Ewers M, Hampel H, Klöppel S, Rami L, Reisberg B, Saykin AJ, Sikkes S, Smart CM, Snitz BE, Sperling R, van der Flier WM, Wagner M, Jessen F. Implementation of subjective cognitive decline criteria in research studies. Alzheimer’s Dementia: The journal of the Alzheimer’s Association. 2017 March;13(3):296-311. PubMed PMID: 27825022; PubMed Central PMCID: PMC5344703.

Mormino EC, Papp KV, Rentz DM, Donohue MC, Amariglio R, Quiroz YT, Chhatwal J, Marshall GA, Donovan N, Jackson J, Gatchel JR, Hanseeuw BJ, Schultz AP, Aisen PS, Johnson KA, Sperling RA. Early and late change on the preclinical Alzheimer’s cognitive composite in clinically normal older individuals with elevated amyloid β. Alzheimers Dementia. Alzheimer’s Association. 2017 September;13(9):1004-1012. PubMed PMID: 28253478; PubMed Central PMCID: PMC5573651.

Papp KV, Rentz DM, Mormino EC, Schultz AP, Amariglio RE, Quiroz Y, Johnson KA, Sperling RA. Cued memory decline in biomarker-defined preclinical Alzheimer disease. Neurology. 2017 April 11;88(15):1431-1438. PubMed PMID: 28283594; PubMed Central PMCID: PMC5386436.

Papp KV, Rentz DM, Orlovsky I, Sperling RA, Mormino EC. Optimizing the preclinical Alzheimer’s cognitive composite with semantic processing: The PACC5. Alzheimer’s Dementia (New York, N. Y.). 2017 November;3(4):668-677. PubMed PMID: 29264389; PubMed Central PMCID: PMC5726754.

Prčkovska V, Huijbers W, Schultz A, Ortiz-Teran L, Peña-Gomez C, Villoslada P, Johnson K, Sperling R, Sepulcre J. Epicenters of dynamic connectivity in the adaptation of the ventral visual system. Human Brain Mapping. 2017 April;38(4):1965-1976. PubMed PMID: 28029725; PubMed Central PMCID: PMC5342908.

Qian J, Hyman BT, Betensky RA. Neurofibrillary Tangle Stage and the Rate of Progression of Alzheimer Symptoms: Modeling Using an Autopsy Cohort and Application to Clinical Trial Design. JAMA Neurology. 2017 May 1;74(5):540-548. PubMed PMID: 28288263; PubMed Central PMCID: PMC5547572.

Qian J, Wolters FJ, Beiser A, Haan M, Ikram MA, Karlawish J, Langbaum JB, Neuhaus JM, Reiman EM, Roberts JS, Seshadri S, Tariot PN, Woods BM, Betensky RA, Blacker D. APOE-related risk of mild cognitive impairment and dementia for prevention trials: An analysis of four cohorts. PLoS Medicine. 2017 March;14(3):e1002254. PubMed PMID: 28323826; PubMed Central PMCID: PMC5360223.

Rentz DM, Mormino EC, Papp KV, Betensky RA, Sperling RA, Johnson KA. Cognitive resilience in clinical and preclinical Alzheimer’s disease: The Association of Amyloid and Tau Burden on cognitive performance. Brain Imaging and Behavior. 2017 April;11(2):383-390. PubMed PMID: 27738998; PubMed Central PMCID: PMC5391311.

Schultz AP, Chhatwal JP, Hedden T, Mormino EC, Hanseeuw BJ, Sepulcre J, Huijbers W, LaPoint M, Buckley RF, Johnson KA, Sperling RA. Phases of Hyperconnectivity and Hypoconnectivity in the Default Mode and Salience Networks Track with Amyloid and Tau in Clinically Normal Individuals. The Journal of Neuroscience. 2017 April 19;37(16):4323-4331. PubMed PMID:28314821; PubMed Central PMCID: PMC5413178.

Sepulcre J, Grothe MJ, Sabuncu M, Chhatwal J, Schultz AP, Hanseeuw B, El Fakhri G, Sperling R, Johnson KA. Hierarchical Organization of Tau and Amyloid Deposits in the Cerebral Cortex. JAMA Neurology. 2017 July 1;74(7):813-820. PubMed PMID: 28558094; PubMed Central PMCID: PMC5710537.

Sepulcre J, Sabuncu MR, Li Q, El Fakhri G, Sperling R, Johnson KA. Tau and amyloid β proteins distinctively associate to functional network changes in the aging brain. Alzheimer’s Dementia. 2017 November;13(11):1261-1269. PubMed PMID: 28366797; PubMed Central PMCID: PMC5623176.

Vannini P, Amariglio R, Hanseeuw B, Johnson KA, McLaren DG, Chhatwal J, Pascual-Leone A, Rentz D, Sperling RA. Memory self-awareness in the preclinical and prodromal stages of Alzheimer’s disease. Neuropsychologia. 2017 May;99:343-349.PubMed PMID: 28385579; PubMed Central PMCID: PMC5473166.

Vannini P, Hanseeuw B, Munro CE, Amariglio RE, Marshall GA, Rentz DM, Pascual- Leone A, Johnson KA, Sperling RA. Anosognosia for memory deficits in mild cognitive impairment: Insight into the neural mechanism using functional and molecular imaging. NeuroImage Clinical. 2017; 15:408-414. PubMed PMID: 28616381; PubMed Central PMCID: PMC5458095.

Vannini P, Hanseeuw B, Munro CE, Amariglio RE, Marshall GA, Rentz DM, Pascual- Leone A, Johnson KA, Sperling RA. Hippocampal hypometabolism in older adults with memory complaints and increased amyloid burden. Neurology. 2017 May 2;88(18):1759-1767. PubMed PMID: 28381517; PubMed Central PMCID: PMC5409840.

Wooten D, Guehl NJ, Verwer EE, Shoup TM, Yokell DL, Zubcevik N, Vasdev N, Zafonte RD, Johnson KA, El Fakhri G, Normandin MD. Pharmacokinetic evaluation of the tau PET radiotracer [18F]T807 ([18F]AV-1451) in human subjects. Journal of Nuclear Medicine, Society of Nuclear Medicine. 2017 March;58(3):484-491. PubMed PMID: 27660144; PubMed Central PMCID: PMC5334185.

Xia C, Makaretz SJ, Caso C, McGinnis S, Gomperts SN, Sepulcre J, Gomez-Isla T, Hyman BT, Schultz A, Vasdev N, Johnson KA, Dickerson BC. Association of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease. JAMA Neurology. 2017 April 1;74(4):427-436. PubMed PMID: 28241163; PubMed Central PMCID: PMC5470368.

Zhang J, Zhou W, Wang L, Zhang X. Gender differences of neuropsychological profiles in cognitively normal older people without amyloid pathology. Comprehensive Psychiatry. 2017 May;75:22-26. PubMed PMID: 28285181; PubMed Central PMCID: PMC5783637.

2016

Atem FD, Qian J, Maye JE, Johnson KA, Betensky RA. Multiple Imputation of a Randomly Censored Covariate Improves Logistic Regression Analysis. Journal of Applied Statistics. 2016;43(15):2886-2896. PubMed PMID: 27713593; PubMed Central PMCID: PMC5047523.

Buckley RF, Villemagne VL, Masters CL, Ellis KA, Rowe CC, Johnson K, Sperling R, Amariglio R. A Conceptualization of the Utility of Subjective Cognitive Decline in Clinical Trials of Preclinical Alzheimer’s Disease. Journal of Molecular Neuroscience: MN. 2016 November;60(3):354-361. PubMed PMID: 27514526; PubMed Central PMCID: PMC5241130.

Chan G, White CC, Winn PA, Cimpean M, Replogle JM, Glick LR, Cuerdon NE, Ryan KJ, Johnson KA, Schneider JA, Bennett DA, Chibnik LB, Sperling RA, De Jager PL, Bradshaw EM. Trans-pQTL study identifies immune crosstalk between Parkinson and Alzheimer loci. Neurology Genetics. 2016 July 26;2(4):e90. PubMed PMID: 27504496; PubMed Central PMCID: PMC4962525.

Chhatwal JP, Schultz AP, Marshall GA, Boot B, Gomez-Isla T, Dumurgier J, LaPoint M, Scherzer C, Roe AD, Hyman BT, Sperling RA, Johnson KA. Temporal T807 binding correlates with CSF tau and phospho-tau in normal elderly. Neurology. 2016 August 30;87(9):920-6. PubMed PMID: 27473132; PubMed Central PMCID: PMC5035159.

Dhilla Albers A, Asafu-Adjei J, Delaney MK, Kelly KE, Gomez-Isla T, Blacker D, Johnson KA, Sperling RA, Hyman BT, Betensky RA, Hastings L, Albers MW. Episodic memory of odors stratifies Alzheimer biomarkers in normal elderly. Annals of Neurology. 2016 December;80(6):846-857. PubMed PMID: 27696605; PubMed Central PMCID: PMC5177522.

Donovan NJ, Okereke OI, Vannini P, Amariglio RE, Rentz DM, Marshall GA, Johnson KA, Sperling RA. Association of Higher Cortical Amyloid Burden with Loneliness in Cognitively Normal Older Adults. JAMA Psychiatry. 2016 December 1;73(12):1230-1237. PubMed PMID: 27806159; PubMed Central PMCID: PMC5257284.

Fotiadis P, van Rooden S, van der Grond J, Schultz A, Martinez-Ramirez S, Auriel E, Reijmer Y, van Opstal AM, Ayres A, Schwab KM, Alzheimer's Disease Neuroimaging Initiative Adni, Hedden T, Rosand J, Viswanathan A, Wermer M, Terwindt GM, Sperling RA, Polimeni JR, Johnson KA, van Buchem MA, Greenberg SM, Gurol ME. Cortical atrophy in patients with cerebral amyloid angiopathy: a case-control study. The Lancet. Neurology. 2016 July;15(8):811-9. PubMed PMID: 27180034; PubMed Central PMCID: PMC5248657.

Gomperts SN, Locascio JJ, Makaretz SJ, Schultz A, Caso C, Vasdev N, Sperling R, Growdon JH, Dickerson BC, Johnson K. Tau Positron Emission Tomographic Imaging in the Lewy Body Diseases. JAMA Neurology. 2016 November 1;73(11):1334-1341. PubMed PMID: 27654968; PubMed Central PMCID: PMC5287290.

Gomperts SN, Marquie M, Locascio JJ, Bayer S, Johnson KA, Growdon JH. PET Radioligands Reveal the Basis of Dementia in Parkinsons Disease and Dementia with Lewy Bodies. Neuro-degenerative Diseases. 2016;16(1-2):118-24. PubMed PMID:26655867; PubMed Central PMCID: PMC4838335.

Greve DN, Salat DH, Bowen SL, Izquierdo-Garcia D, Schultz AP, Catana C, Becker JA, Svarer C, Knudsen GM, Sperling RA, Johnson KA. Different partial volume correction methods lead to different conclusions: An (18)F-FDG-PET study of aging. NeuroImage.2016 May 15;132:334-43. PubMed PMID: 26915497; PubMed Central PMCID: PMC4851886.

Gurol ME, Becker JA, Fotiadis P, Riley G, Schwab K, Johnson KA, Greenberg SM. Florbetapir-PET to diagnose cerebral amyloid angiopathy: A prospective study. Neurology. 2016 November 8;87(19):2043-2049. PubMed PMID: 27605173; PubMed Central PMCID: PMC5109947.

Hanseeuw BJ, Schultz AP, Betensky RA, Sperling RA, Johnson KA. Decreased hippocampal metabolism in high-amyloid mild cognitive impairment. Alzheimer’s Dementia. The Journal of the Alzheimer’s Association. 2016 December;12(12):1288-1296. PubMed PMID: 27421609; PubMed Central PMCID: PMC5148703.

Jack CR Jr, Bennett DA, Blennow K, Carrillo MC, Feldman HH, Frisoni GB, Hampel H, Jagust WJ, Johnson KA, Knopman DS, Petersen RC, Scheltens P, Sperling RA, Dubois B. A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers. Neurology. 2016 August 2;87(5):539-47. PubMed PMID: 27371494; PubMed Central PMCID: PMC4970664.

Johnson KA, Schultz A, Betensky RA, Becker JA, Sepulcre J, Rentz D, Mormino E, Chhatwal J, Amariglio R, Papp K, Marshall G, Albers M, Mauro S, Pepin L, Alverio J, Judge K, Philiossaint M, Shoup T, Yokell D, Dickerson B, Gomez-Isla T, Hyman B, Vasdev N, Sperling R. Tau positron emission tomographic imaging in aging and early Alzheimer disease. Annals of Neurology. 2016 January;79(1):110-9. PubMed PMID: 26505746; PubMed Central PMCID: PMC4738026.

Mormino EC, Papp KV, Rentz DM, Schultz AP, LaPoint M, Amariglio R, Hanseeuw B, Marshall GA, Hedden T, Johnson KA, Sperling RA. Heterogeneity in Suspected Non- Alzheimer Disease Pathophysiology Among Clinically Normal Older Individuals. JAMA Neurology. 2016 October 1;73(10):1185-1191. PubMed PMID: 27548655; PubMed Central PMCID: PMC5266522.

Mormino EC, Sperling RA, Holmes AJ, Buckner RL, De Jager PL, Smoller JW, Sabuncu MR. Polygenic risk of Alzheimer disease is associated with early- and late-life processes. Neurology. 2016 August 2;87(5):481-8. PubMed PMID: 27385740; PubMed Central PMCID: PMC4970660.

Papp KV, Mormino EC, Amariglio RE, Munro C, Dagley A, Schultz AP, Johnson KA, Sperling RA, Rentz DM. Biomarker validation of a decline in semantic processing in preclinical Alzheimer’s Disease. Neuropsychology. 2016 July;30(5):624-30. PubMed PMID: 26595826; PubMed Central PMCID: PMC4877295.

Rentz DM, Dekhtyar M, Sherman J, Burnham S, Blacker D, Aghjayan SL, Papp KV, Amariglio RE, Schembri A, Chenhall T, Maruff P, Aisen P, Hyman BT, Sperling RA. The Feasibility of At-Home iPad Cognitive Testing for Use in Clinical Trials. The Journal of Prevention of Alzheimer’s Disease. 2016 March;3(1):8-12. PubMed PMID:26998469; PubMed Central PMCID: PMC4795477.

Rieckmann A, Hedden T, Younger AP, Sperling RA, Johnson KA, Buckner RL. Dopamine transporter availability in clinically normal aging is associated with individual differences in white matter integrity. Human Brain Mapping. 2016 Feb;37(2):621-31. PubMed PMID: 26542307; PubMed Central PMCID: PMC4729206.

Rieckmann A, Van Dijk KR, Sperling RA, Johnson KA, Buckner RL, Hedden T. Accelerated decline in white matter integrity in clinically normal individuals at risk for Alzheimer’s Disease. Neurobiology of Aging. 2016 June; 42:177-88. PubMed PMID: 27143434; PubMed Central PMCID: PMC4857135.

Sepulcre J, Schultz AP, Sabuncu M, Gomez-Isla T, Chhatwal J, Becker A, Sperling R, Johnson KA. In Vivo Tau, Amyloid, and Gray Matter Profiles in the Aging Brain. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience. 2016 July13;36(28):7364-74. PubMed PMID: 27413148; PubMed Central PMCID: PMC4945661.

Zhang X, Mormino EC, Sun N, Sperling RA, Sabuncu MR, Yeo BT. Bayesian model reveals latent atrophy factors with dissociable cognitive trajectories in Alzheimer’s disease. Proceedings of the National Academy of Sciences of the United States of America. 2016 October 18;113(42):E6535-E6544. PubMed PMID: 27702899; PubMed Central PMCID: PMC5081632.

2015

Amariglio RE, Mormino EC, Pietras AC, Marshall GA, Vannini P, Johnson KA, Sperling RA, Rentz DM. Subjective cognitive concerns, amyloid-β, and neurodegeneration in clinically normal elderly. Neurology. 2015 Jul 7;85(1):56-62. PubMed PMID: 26048028; PubMed Central PMCID: PMC4501939.

Auriel E, Westover MB, Bianchi MT, Reijmer Y, Martinez-Ramirez S, Ni J, Van Etten E, Frosch MP, Fotiadis P, Schwab K, Vashkevich A, Boulouis G, Younger AP, Johnson KA, Sperling RA, Hedden T, Gurol ME, Viswanathan A, Greenberg SM. Estimating Total Cerebral Microinfarct Burden From Diffusion-Weighted Imaging. Stroke. 2015 Aug;46(8):2129-35. PubMed PMID: 26159796; PubMed Central PMCID: PMC4519384.

Chan G, White CC, Winn PA, Cimpean M, Replogle JM, Glick LR, Cuerdon NE, Ryan KJ, Johnson KA, Schneider JA, Bennett DA, Chibnik LB, Sperling RA, Bradshaw EM, DeJager PL. CD33 modulates TREM2: convergence of Alzheimer loci. Nat Neuroscience. 2015 Nov;18(11):1556-8. PubMed PMID: 26414614; PubMed Central PMCID: PMC4682915.

Donovan NJ, Hsu DC, Dagley AS, Schultz AP, Amariglio RE, Mormino EC, Okereke OI, Rentz DM, Johnson KA, Sperling RA, Marshall GA. Depressive Symptoms and Biomarkers of Alzheimer’s Disease in Cognitively Normal Older Adults. J Alzheimer’s Disease. 2015;46(1):63-73. PubMed PMID: 25697700; PubMed Central PMCID: PMC4544638.

Gidicsin CM, Maye JE, Locascio JJ, Pepin LC, Philiossaint M, Becker JA, Younger AP, Dekhtyar M, Schultz AP, Amariglio RE, Marshall GA, Rentz DM, Hedden T, Sperling RA, Johnson KA. Cognitive activity relates to cognitive performance but not to Alzheimer disease biomarkers. Neurology. 2015 Jul 7;85(1):48-55. PubMed PMID: 26062627; PubMed Central PMCID: PMC4501938.

Growdon ME, Schultz AP, Dagley AS, Amariglio RE, Hedden T, Rentz DM, Johnson KA, Sperling RA, Albers MW, Marshall GA. Odor identification and Alzheimer disease biomarkers in clinically normal elderly. Neurology. 2015 May 26;84(21):2153-60. PubMed PMID: 25934852; PubMed Central PMCID: PMC4451046.

Malishkevich A, Marshall GA, Schultz AP, Sperling RA, Aharon-Peretz J, Gozes I. Blood-Borne Activity-Dependent Neuroprotective Protein (ADNP) is Correlated with Premorbid Intelligence, Clinical Stage, and Alzheimer’s Disease Biomarkers. J Alzheimers Disease. 2015 Nov 30;50(1):249-60. PubMed PMID: 26639975; PubMed Central PMCID: PMC4712084.

Marquié M, Normandin MD, Vanderburg CR, Costantino IM, Bien EA, Rycyna LG, Klunk WE, Mathis CA, Ikonomovic MD, Debnath ML, Vasdev N, Dickerson BC, Gomperts SN, Growdon JH, Johnson KA, Frosch MP, Hyman BT, Gómez-Isla T. Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue. Annals of Neurology. 2015 November;78(5):787-800. PubMed PMID: 26344059; PubMed Central PMCID: PMC4900162.

Marshall GA, Dekhtyar M, Bruno JM, Jethwani K, Amariglio RE, Johnson KA, Sperling RA, Rentz DM. The Harvard Automated Phone Task: new performance-based activities of daily living tests for early Alzheimer’s disease. J Prev Alzheimers Disease. 2015Dec;2(4):242-253. PubMed PMID: 26665121; PubMed Central PMCID: PMC4671513.

Papp KV, Amariglio RE, Mormino EC, Hedden T, Dekhytar M, Johnson KA, Sperling RA, Rentz DM. Free and cued memory in relation to biomarker-defined abnormalities in clinically normal older adults and those at risk for Alzheimer’s disease. Neuropsychologia. 2015 July;73:169-75. PubMed PMID: 26002757; PubMed Central PMCID: PMC4479270.

Rabin LA, Smart CM, Crane PK, Amariglio RE, Berman LM, Boada M, Buckley RF, Chételat G, Dubois B, Ellis KA, Gifford KA, Jefferson AL, Jessen F, Katz MJ, Lipton RB, Luck T, Maruff P, Mielke MM, Molinuevo JL, Naeem F, Perrotin A, Petersen RC, Rami L, Reisberg B, Rentz DM, Riedel-Heller SG, Risacher SL, Rodriguez O, Sachdev PS, Saykin AJ, Slavin MJ, Snitz BE, Sperling RA, Tandetnik C, van der Flier WM, Wagner M, Wolfsgruber S, Sikkes SA. Subjective Cognitive Decline in Older Adults: An Overview of Self-Report Measures Used Across 19 International Research Studies. J Alzheimers Disease. 2015 Sep 24;48 Suppl1:S63-86. PubMed PMID: 26402085; PubMed Central PMCID: PMC4617342.

Reijmer YD, Schultz AP, Leemans A, O’Sullivan MJ, Gurol ME, Sperling R, Greenberg SM, Viswanathan A, Hedden T. Decoupling of structural and functional brain connectivity in older adults with white matter hyperintensities. Neuroimage. 2015 Aug 15;117:222-9. PubMed PMID: 26025290; PubMed Central PMCID: PMC4511724.

Replogle JM, Chan G, White CC, Raj T, Winn PA, Evans DA, Sperling RA, Chibnik LB, Bradshaw EM, Schneider JA, Bennett DA, De Jager PL. A TREM1 variant alters the accumulation of Alzheimer-related amyloid pathology. Ann Neurol. 2015 Mar;77(3):469-77. PubMed PMID: 25545807; PubMed Central PMCID: PMC4461024.

Shaw EE, Schultz AP, Sperling RA, Hedden T. Functional Connectivity in Multiple Cortical Networks Is Associated with Performance Across Cognitive Domains in Older Adults. Brain Connect. 2015 Oct;5(8):505-16. PubMed PMID: 25827242; PubMed Central PMCID: PMC4601675.

Sperling RA, Amariglio RE, Marshall GA, Rentz DM. Establishing Clinical Relevance in Preclinical Alzheimer’s Disease. J Prev Alzheimers Disease. 2015 Jun;2(2):85-87. PubMed PMID: 26247003; PubMed Central PMCID: PMC4523117.

Toledo JB, Zetterberg H, van Harten AC, Glodzik L, Martinez-Lage P, Bocchio-Chiavetto L, Rami L, Hansson O, Sperling R, Engelborghs S, Osorio RS, Vanderstichele H, Vandijck M, Hampel H, Teipl S, Moghekar A, Albert M, Hu WT, Monge Argilés JA, Gorostidi A, Teunissen CE, De Deyn PP, Hyman BT, Molinuevo JL, Frisoni GB, Linazasoro G, de Leon MJ, van der Flier WM, Scheltens P, Blennow K, Shaw LM, Trojanowski JQ, Alzheimer’s Disease Neuroimaging Initiative. Alzheimer’s disease cerebrospinal fluid biomarker in cognitively normal subjects. Brain. 2015 Sep;138(Pt9):2701-15. PubMed PMID: 26220940; PubMed Central PMCID: PMC4643624.

2014

Schultz, A. P., Chhatwal, J. P., Huijbers, W., Hedden, T., Van Dijk, K. R., McLaren, D. G., … & Sperling, R. A. (2014). Template based rotation: a method for functional connectivity analysis with a priori templates. Neuroimage102, 620-636.

Sperling, R. A., Rentz, D. M., Johnson, K. A., Karlawish, J., Donohue, M., Salmon, D. P., & Aisen, P. (2014). The A4 study: stopping AD before symptoms begin?. Science translational medicine6(228), 228fs13-228fs13. 
Serrano-Pozo A, Qian J, Monsell SE, Blacker D, Gómez-Isla T, Betensky RA, Growdon JH, Johnson K, Frosch MP, Sperling RA, Hyman BT (2014). Mild to Moderate Alzheimer Dementia with Insufficient Neuropathological Changes. Annals of Neurology, PMID: 24585367
 
Huijbers W, Mormino E, Wigman S, Ward A, Vannini P, McLaren D, Becker J, Schultz A, Hedden T, Johnson K, and Sperling R (2014). Amyloid deposition is linked to aberrant entorhinal activity among cognitively normal older adults. Journal of Neuroscience, 34(15), 5200-10.
 
Papp, K. V., Amariglio, R. E., Dekhtyar, M., Roy, K., Wigman, S., Bamfo, R., … & Rentz, D. M. (2014). Development of a psychometrically equivalent short form of the face–name associative memory exam for use along the early alzheimer’s disease trajectory. The Clinical Neuropsychologist28(5), 771-785.

Mormino, E. C., Betensky, R. A., Hedden, T., Schultz, A. P., Ward, A., Huijbers, W., … & Alzheimer’s Disease Neuroimaging Initiative. (2014). Amyloid and APOE ε4 interact to influence short-term decline in preclinical Alzheimer disease. Neurology82(20), 1760-1767. 

2013

Bradshaw, E. M., Chibnik, L. B., Keenan, B. T., Ottoboni, L., Raj, T., Tang, A., … & Morris, M. C. (2013). CD33 Alzheimer’s disease locus: altered monocyte function and amyloid biology. Nature neuroscience16(7), 848.

Gomperts SN, Johnson KA, Growdon J (2013). Beyond the limits of detection: failure of PiB imaging to capture true Aβ burden. Movement Disorders, 28(3), 407.

Gomperts, S. N., Locascio, J. J., Rentz, D., Santarlasci, A., Marquie, M., Johnson, K. A., & Growdon, J. H. (2013). Amyloid is linked to cognitive decline in patients with Parkinson disease without dementia. Neurology80(1), 85-91.
 
Hedden, T., Oh, H., Younger, A. P., & Patel, T. A. (2013). Meta-analysis of amyloid-cognition relations in cognitively normal older adults. Neurology80(14), 1341-1348.

Huijbers, W., Schultz, A. P., Vannini, P., McLaren, D. G., Wigman, S. E., Ward, A. M., … & Sperling, R. A. (2013). The encoding/retrieval flip: interactions between memory performance and memory stage and relationship to intrinsic cortical networks. Journal of cognitive neuroscience25(7), 1163-1179.

Johnson, K. A., Minoshima, S., Bohnen, N. I., Donohoe, K. J., Foster, N. L., Herscovitch, P., … & Hedrick, S. (2013). Appropriate use criteria for amyloid PET: a report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer’s Association. Journal of Nuclear Medicine54(3), 476-490.

Johnson, K. A., Sperling, R. A., Gidicsin, C. M., Carmasin, J. S., Maye, J. E., Coleman, R. E., … & Doraiswamy, P. M. (2013). Florbetapir (F18-AV-45) PET to assess amyloid burden in Alzheimer’s disease dementia, mild cognitive impairment, and normal aging. Alzheimer’s & Dementia9(5), S72-S83.

Li, S., Jin, M., Zhang, D., Yang, T., Koeglsperger, T., Fu, H., & Selkoe, D. J. (2013). Environmental novelty activates β2-adrenergic signaling to prevent the impairment of hippocampal LTP by Aβ oligomers. Neuron77(5), 929-941. 

Marshall, G. A., Donovan, N. J., Lorius, N., Gidicsin, C. M., Maye, J., Pepin, L. C., … & Johnson, K. A. (2013). Apathy is associated with increased amyloid burden in mild cognitive impairment. The Journal of neuropsychiatry and clinical neurosciences25(4), 302-307.

Perez-Nievas, B. G., Stein, T. D., Tai, H. C., Dols-Icardo, O., Scotton, T. C., Barroeta-Espar, I., … & Serrano-Pozo, A. (2013). Dissecting phenotypic traits linked to human resilience to Alzheimer’s pathology. Brain136(8), 2510-2526.

Sepulcre, J., Sabuncu, M. R., Becker, A., Sperling, R., & Johnson, K. A. (2013). In vivo characterization of the early states of the amyloid-beta network. Brain136(7), 2239-2252. 

 Sperling, R. A., Johnson, K. A., Doraiswamy, P. M., Reiman, E. M., Fleisher, A. S., Sabbagh, M. N., … & Flitter, M. (2013). Amyloid deposition detected with florbetapir F 18 (18F-AV-45) is related to lower episodic memory performance in clinically normal older individuals. Neurobiology of aging34(3), 822-831.

Ward, A. M., McLaren, D. G., Schultz, A. P., Chhatwal, J., Boot, B. P., Hedden, T., & Sperling, R. A. (2013). Daytime sleepiness is associated with decreased default mode network connectivity in both young and cognitively intact elderly subjects. Sleep36(11), 1609-1615.
 
Ward, A. M., Schultz, A. P., Huijbers, W., Van Dijk, K. R., Hedden, T., & Sperling, R. A. (2014). The parahippocampal gyrus links the default‐mode cortical network with the medial temporal lobe memory system. Human brain mapping35(3), 1061-1073.

2012

Amariglio, R. E., Becker, J. A., Carmasin, J., Wadsworth, L. P., Lorius, N., Sullivan, C., … & Johnson, K. A. (2012). Subjective cognitive complaints and amyloid burden in cognitively normal older individuals. Neuropsychologia50(12), 2880-2886.

Amariglio, R. E., Frishe, K., Olson, L. E., Wadsworth, L. P., Lorius, N., Sperling, R. A., & Rentz, D. M. (2012). Validation of the Face Name Associative Memory Exam in cognitively normal older individuals. Journal of clinical and experimental neuropsychology34(6), 580-587.

Chhatwal, J. P., & Sperling, R. A. (2012). Functional MRI of mnemonic networks across the spectrum of normal aging, mild cognitive impairment, and Alzheimer’s disease. Journal of Alzheimer’s Disease31(s3), S155-S167.

Desikan, R. S., McEvoy, L. K., Thompson, W. K., Holland, D., Brewer, J. B., Aisen, P. S., … & Alzheimer’s Disease Neuroimaging Initiative. (2012). Amyloid-β–associated clinical decline occurs only in the presence of elevated p-tau. Archives of neurology69(6), 709-713.

Doraiswamy PM, Sperling RA, Coleman RE, Johnson KA, Reiman EM, Davis MD, Grundman M, Sabbagh MN, Sadowsky CH, Fleisher AS, Carpenter A, Clark CM, Joshi AD, Mintun MA, Skovronsky DM, Pontecorvo MJ; AV45-A11 Study Group. Amyloid-β assessed by florbetapir F 18 PET and 18-month cognitive decline: a multicenter study. Neurology, 79(16),1636-44.

Fleisher, A. S., Chen, K., Liu, X., Ayutyanont, N., Roontiva, A., Thiyyagura, P., … & Sperling, R. A. (2013). Apolipoprotein E ε4 and age effects on florbetapir positron emission tomography in healthy aging and Alzheimer disease. Neurobiology of aging34(1), 1-12.

Gomperts, S. N., Locascio, J. J., Marquie, M., Santarlasci, A. L., Rentz, D. M., Maye, J., … & Growdon, J. H. (2012). Brain amyloid and cognition in Lewy body diseases. Movement Disorders27(8), 965-973.

Gurol, M. E., Viswanathan, A., Gidicsin, C., Hedden, T., Martinez-Ramirez, S., Dumas, A., … & Becker, A. (2013). Cerebral amyloid angiopathy burden associated with leukoaraiosis: a positron emission tomography/magnetic resonance imaging study. Annals of neurology73(4), 529-536.

Huijbers, W., Vannini, P., Sperling, R. A., Pennartz, C. M., Cabeza, R., & Daselaar, S. M. (2012). Explaining the encoding/retrieval flip: memory-related deactivations and activations in the posteromedial cortex. Neuropsychologia50(14), 3764-3774.

Hedden, T., Van Dijk, K. R., Shire, E. H., Sperling, R. A., Johnson, K. A., & Buckner, R. L. (2011). Failure to modulate attentional control in advanced aging linked to white matter pathology. Cerebral Cortex22(5), 1038-1051.

Hedden, T., Mormino, E. C., Amariglio, R. E., Younger, A. P., Schultz, A. P., Becker, J. A., … & Rentz, D. M. (2012). Cognitive profile of amyloid burden and white matter hyperintensities in cognitively normal older adults. Journal of Neuroscience32(46), 16233-16242.

Nordberg A, Petersen RC, Reiman EM, Selkoe DJ, Sperling RA, Van Laere K, Weiner MW, Drzezga A. (2012). Aβ Imaging: feasible, pertinent, and vital to progress in Alzheimer’s disease. European Journal of Nuclear Medicine and Molecular Imaging, 39(2),209-19.

Sabuncu, M. R., Buckner, R. L., Smoller, J. W., Lee, P. H., Fischl, B., Sperling, R. A., & Alzheimer’s Disease Neuroimaging Initiative. (2011). The association between a polygenic Alzheimer score and cortical thickness in clinically normal subjects. Cerebral cortex22(11), 2653-2661.
 
Sepulcre, J., Sabuncu, M. R., Yeo, T. B., Liu, H., & Johnson, K. A. (2012). Stepwise connectivity of the modal cortex reveals the multimodal organization of the human brain. Journal of Neuroscience32(31), 10649-10661.
 
Townsend, M. K., Okereke, O. I., Xia, W., Yang, T., Selkoe, D. J., & Grodstein, F. (2012). The relation between insulin, insulin-related factors, and plasma amyloid beta peptide levels at mid-life in a population-based study. Alzheimer disease and associated disorders26(1), 50.

Vannini, P., Hedden, T., Becker, J. A., Sullivan, C., Putcha, D., Rentz, D., … & Sperling, R. A. (2012). Age and amyloid-related alterations in default network habituation to stimulus repetition. Neurobiology of aging33(7), 1237-1252.

Vannini, P., Hedden, T., Huijbers, W., Ward, A., Johnson, K. A., & Sperling, R. A. (2012). The ups and downs of the posteromedial cortex: age-and amyloid-related functional alterations of the encoding/retrieval flip in cognitively normal older adults. Cerebral Cortex23(6), 1317-1328.

Vannini, P., Hedden, T., Sullivan, C., & Sperling, R. A. (2013). Differential functional response in the posteromedial cortices and hippocampus to stimulus repetition during successful memory encoding. Human brain mapping34(7), 1568-1578.

Villemagne VL, Klunk WE, Mathis CA, Rowe CC, Brooks DJ, Hyman BT, Ikonomovic MD, Ishii K, Jack CR, Jagust WJ, Johnson KA, Koeppe RA, Lowe VJ, Masters CL, Montine TJ, Morris JC, Yang, T., Hong, S., O’Malley, T., Sperling, R. A., Walsh, D. M., & Selkoe, D. J. (2013). New ELISAs with high specificity for soluble oligomers of amyloid β-protein detect natural Aβ oligomers in human brain but not CSF. Alzheimer’s & Dementia9(2), 99-112.

2011

Amariglio, R. E., Townsend, M. K., Grodstein, F., Sperling, R. A., & Rentz, D. M. (2011). Specific subjective memory complaints in older persons may indicate poor cognitive function. Journal of the American Geriatrics Society59(9), 1612-1617.

Atri, A., O’brien, J. L., Sreenivasan, A., Rastegar, S., Salisbury, S., DeLuca, A. N., … & Sperling, R. A. (2011). Test-retest reliability of memory task functional magnetic resonance imaging in Alzheimer disease clinical trials. Archives of neurology68(5), 599-606.

Becker, J. A., Hedden, T., Carmasin, J., Maye, J., Rentz, D. M., Putcha, D., … & Marks, D. (2011). Amyloid‐β associated cortical thinning in clinically normal elderly. Annals of neurology69(6), 1032-1042.

Dickerson, B. C., Stoub, T. R., Shah, R. C., Sperling, R. A., Killiany, R. J., Albert, M. S., … & Blacker, D. (2011). Alzheimer-signature MRI biomarker predicts AD dementia in cognitively normal adults. Neurology76(16), 1395-1402.
  
Drzezga, A., Becker, J. A., Van Dijk, K. R., Sreenivasan, A., Talukdar, T., Sullivan, C., … & Johnson, K. A. (2011). Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden. Brain134(6), 1635-1646.
 
Freir, D. B., Fedriani, R., Scully, D., Smith, I. M., Selkoe, D. J., Walsh, D. M., & Regan, C. M. (2011). Aβ oligomers inhibit synapse remodelling necessary for memory consolidation. Neurobiology of aging32(12), 2211-2218.

Hong, S., Quintero-Monzon, O., Ostaszewski, B. L., Podlisny, D. R., Cavanaugh, W. T., Yang, T., … & Selkoe, D. J. (2011). Dynamic analysis of amyloid β-protein in behaving mice reveals opposing changes in ISF versus parenchymal Aβ during age-related plaque formation. Journal of Neuroscience31(44), 15861-15869.

Jack Jr, C. R., Albert, M. S., Knopman, D. S., McKhann, G. M., Sperling, R. A., Carrillo, M. C., … & Phelps, C. H. (2011). Introduction to the recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimer’s & Dementia7(3), 257-262.
 
Jin, M., Shepardson, N., Yang, T., Chen, G., Walsh, D., & Selkoe, D. J. (2011). Soluble amyloid β-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration. Proceedings of the National Academy of Sciences108(14), 5819-5824.
 
Li, S., Jin, M., Koeglsperger, T., Shepardson, N. E., Shankar, G. M., & Selkoe, D. J. (2011). Soluble Aβ oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors. Journal of Neuroscience31(18), 6627-6638.
  
Marshall, G. A., Olson, L. E., Frey, M. T., Maye, J., Becker, J. A., Rentz, D. M., … & Alzheimer’s Disease Neuroimaging Initiative. (2011). Instrumental activities of daily living impairment is associated with increased amyloid burden. Dementia and geriatric cognitive disorders31(6), 443-450.

Mattsson, N., Andreasson, U., Persson, S., Arai, H., Batish, S. D., Bernardini, S., … & Coart, E. (2011). The Alzheimer’s Association external quality control program for cerebrospinal fluid biomarkers. Alzheimer’s & Dementia7(4), 386-395.

Pihlajamäki, M., O’Keefe, K., O’Brien, J., Blacker, D., & Sperling, R. A. (2011). Failure of repetition suppression and memory encoding in aging and Alzheimer’s disease. Brain imaging and behavior5(1), 36-44.

Putcha, D., Brickhouse, M., O’Keefe, K., Sullivan, C., Rentz, D., Marshall, G., … & Sperling, R. (2011). Hippocampal hyperactivation associated with cortical thinning in Alzheimer’s disease signature regions in non-demented elderly adults. Journal of Neuroscience31(48), 17680-17688.
 
Putcha, D., O’keefe, K., LaViolette, P., O’brien, J., Greve, D., Rentz, D. M., … & Sperling, R. (2011). Reliability of functional magnetic resonance imaging associative encoding memory paradigms in non‐demented elderly adults. Human brain mapping32(12), 2027-2044.

Rentz, D. M., Amariglio, R. E., Becker, J. A., Frey, M., Olson, L. E., Frishe, K., … & Sperling, R. A. (2011). Face-name associative memory performance is related to amyloid burden in normal elderly. Neuropsychologia49(9), 2776-2783.
 
Sperling, R. A., Aisen, P. S., Beckett, L. A., Bennett, D. A., Craft, S., Fagan, A. M., … & Park, D. C. (2011). Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimer’s & dementia7(3), 280-292.

Vannini, P., O’brien, J., O’keefe, K., Pihlajamäki, M., Laviolette, P., & Sperling, R. A. (2010). What goes down must come up: role of the posteromedial cortices in encoding and retrieval. Cerebral Cortex21(1), 22-34.

Wang, J., & Chang, C. I. (2006). Independent component analysis-based dimensionality reduction with applications in hyperspectral image analysis. IEEE transactions on geoscience and remote sensing44(6), 1586-1600.

2010

Rentz, D. M., Locascio, J. J., Becker, J. A., Moran, E. K., Eng, E., Buckner, R. L., … & Johnson, K. A. (2010). Cognition, reserve, and amyloid deposition in normal aging. Annals of neurology67(3), 353-364.

Sperling, R. A., Dickerson, B. C., Pihlajamaki, M., Vannini, P., LaViolette, P. S., Vitolo, O. V., … & Johnson, K. A. (2010). Functional alterations in memory networks in early Alzheimer’s disease. Neuromolecular medicine12(1), 27-43.
 
Wang, L., LaViolette, P., O’Keefe, K., Putcha, D., Bakkour, A., Van Dijk, K. R., … & Sperling, R. A. (2010). Intrinsic connectivity between the hippocampus and posteromedial cortex predicts memory performance in cognitively intact older individuals. Neuroimage51(2), 910-917.
 
Wang, L., Negreira, A., LaViolette, P., Bakkour, A., Sperling, R. A., & Dickerson, B. C. (2010). Intrinsic interhemispheric hippocampal functional connectivity predicts individual differences in memory performance ability. Hippocampus20(3), 345-351.

2009

Buckner, R. L., Sepulcre, J., Talukdar, T., Krienen, F. M., Liu, H., Hedden, T., … & Johnson, K. A. (2009). Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer’s disease. Journal of neuroscience29(6), 1860-1873.
 
Sperling, R. A., LaViolette, P. S., O’Keefe, K., O’Brien, J., Rentz, D. M., Pihlajamaki, M., … & Buckner, R. L. (2009). Amyloid deposition is associated with impaired default network function in older persons without dementia. Neuron63(2), 178-188.
 
Hedden, T., Van Dijk, K. R., Becker, J. A., Mehta, A., Sperling, R. A., Johnson, K. A., & Buckner, R. L. (2009). Disruption of functional connectivity in clinically normal older adults harboring amyloid burden. Journal of Neuroscience29(40), 12686-12694.

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