Dorene M. Rentz, PsyD, is a clinical neuropsychologist with dual appointments in the Departments of Neurology at Brigham and Women’s Hospital and Massachusetts General Hospital. She is an Associate Professor of Neurology at Harvard Medical School and serves as the Co-Director of the Center for Alzheimer Research and Treatment and the Director of Neuropsychology at the Massachusetts Alzheimer’s Disease Research Center. She is also the Clinical Core Leader of the Harvard Aging Brain Study and the Director of the Recruitment and Outreach Core. Her research focus has been on the early detection of preclinical Alzheimer’s disease, particularly in high functioning individuals. Her recent work involves exploring early cognitive changes using PET amyloid and tau imaging and sensitive memory techniques. She is leading the cognitive outcome assessment committee for the A4 secondary prevention trial in Preclinical Alzheimer’s disease and is a leader in developing optimal cognitive outcome measures for future Alzheimer Disease prevention studies. She helped develop the iPad cognitive battery in the A4 study and has explored the feasibility of doing iPad cognitive assessments in the clinic and home environments.