Publications

Below are all manuscripts written by the Harvard Aging Brain Study from 2009 – 2020. Last updated: July 2020

2025

Capogna E, Sorensen O, Watne LO, Roe J, Stromstad M, Idland AV, Halaas NB, Blennow K, Zetterberg H, Walhovd KB, Alzheimer’s Disease Neuroimaging I, Australian Imaging B, Lifestyle flagship study of a, Fjell AM, Vidal-Pineiro D. Subtypes of brain change in aging and their associations with cognition and Alzheimer’s disease biomarkers. Neurobiol Aging. 2025;147:124-40. Epub 20241226. doi: 10.1016/j.neurobiolaging.2024.12.009. PubMed PMID: 39740372. 

Coughlan GT, Klinger HM, Boyle R, Betthauser TJ, Binette AP, Christenson L, Chadwick T, Hansson O, Harrison TM, Healy B, Jacobs HIL, Hanseeuw B, Jonaitis E, Jack CR, Jr., Johnson KA, Langhough RE, Properzi MJ, Rentz DM, Schultz AP, Smith R, Seto M, Johnson SC, Mielke MM, Shirzadi Z, Yau WW, Manson JE, Sperling RA, Vemuri P, Buckley RF, Alzheimer’s Disease Neuroimaging I. Sex Differences in Longitudinal Tau-PET in Preclinical Alzheimer Disease: A Meta-Analysis. JAMA Neurol. 2025;82(4):364-75. Epub 20250303. doi: 10.1001/jamaneurol.2025.0013. PubMed PMID: 40029638; PMCID: PMC11877413. 

Coughlan GT, Rubinstein Z, Klinger H, Lopez KA, Hsieh S, Boyle R, Seto M, Townsend D, Mayblyum D, Thibault E, Jacobs HIL, Farrell M, Rabin JS, Papp K, Amariglio R, Baker S, Lois C, Rentz D, Price J, Schultz A, Properzi M, Johnson K, Sperling R, Buckley RF. Associations between hormone therapy use and tau accumulation in brain regions vulnerable to Alzheimer’s disease. Sci Adv. 2025;11(10):eadt1288. Epub 20250305. doi: 10.1126/sciadv.adt1288. PubMed PMID: 40043125; PMCID: PMC11881894. 

Jutten RJ, Soberanes D, Molinare CP, Hsieh S, Farrell ME, Schultz AS, Rentz DM, Marshall GA, Johnson KA, Sperling RA, Amariglio RE, Papp KV. Detecting early cognitive deficits in preclinical Alzheimer’s disease using a remote digital multi-day learning paradigm. NPJ Digit Med. 2025;8(1):24. Epub 20250113. doi: 10.1038/s41746-024-01347-7. PubMed PMID: 39806194; PMCID: PMC11729905. 

Kuhn E, Klinger HM, Amariglio RE, Wagner M, Jessen F, Duzel E, Heneka MT, Chetelat G, Rentz DM, Sperling RA, Ebenau JL, Butterbrod E, Van Der Flier WM, Sikkes SAM, Teunnissen CE, Van Harten AC, Van De Giessen EM, Rami L, Tort A, Sanchez Benavides G, Gifford KA, Van Hulle C, Buckley RF, Alzheimer’s Disease Neuroimaging I, Australian Imaging B, Lifestyle flagship study of ageing AST, Study D, Harvard Aging Brain S. SCD-plus features and AD biomarkers in cognitively unimpaired samples: A meta-analytic approach for nine cohort studies. Alzheimers Dement. 2025. Epub 20250222. doi: 10.1002/alz.14307. PubMed PMID: 39985404. 

Terao CM, Alexander MW, Chalmers RP, Boshmaf SZ, Paterson J, Black SE, Papp KV, Sperling RA, Rabin JS. Identifying cognitive test scores associated with early tau burden in Alzheimer’s disease. Alzheimers Dement (Amst). 2025;17(1):e70052. Epub 20250114. doi: 10.1002/dad2.70052. PubMed PMID: 39811702; PMCID: PMC11730071. 

Weizenbaum EL, Hsieh S, Molinare C, Soberanes D, Christiano C, Viera AMR, Anzai JAU, Moreno S, Campbell EC, Yang HS, Marshall GA, Sperling RA, Papp KV, Amariglio RE. Validation of the multi-day Boston remote assessment of neurocognitive health (BRANCH) among cognitively impaired & unimpaired older adults. J Prev Alzheimers Dis. 2025;12(3):100057. Epub 20250113. doi: 10.1016/j.tjpad.2025.100057. PubMed PMID: 39809614. 

Wiels WA, Oomens JE, Engelborghs S, Baeken C, von Arnim CAF, Boada M, Didic M, Dubois B, Fladby T, van der Flier WM, Frisoni GB, Frohlich L, Gill KD, Grimmer T, Hildebrandt H, Hort J, Itoh Y, Iwatsubo T, Klimkowicz-Mrowiec A, Lee DY, Lleo A, Martinez-Lage P, de Mendonca A, Meyer PT, Kapaki EN, Parchi P, Pardini M, Parnetti L, Popp J, Rami L, Reiman EM, Rinne JO, Rodrigue KM, Sanchez-Juan P, Santana I, Sarazin M, Scarmeas N, Skoog I, Snyder PJ, Sperling RA, Villeneuve S, Wallin A, Wiltfang J, Zetterberg H, Ossenkoppele R, Verhey FRJ, Vos SJB, Visser PJ, Jansen WJ, Amyloid Biomarker Study g, Alzheimer’s Disease Neuroimaging Initiative tASgDIANEPoAsDcFACEHBIHA, Alcolea D, Altomare D, Baiardi S, Baldeiras I, Bateman RJ, Blennow K, Bottlaender M, den Braber A, van Buchem MA, Byun MS, Cerman J, Chen K, Chipi E, Day GS, Drzezga A, Eckerstrom M, Ekblad LL, Epelbaum S, Forster S, Fortea J, Freund-Levi Y, Frings L, Guedj E, Hausner L, Hellwig S, Huey ED, Jimenez-Bonilla JF, Johnson KA, Juaristi AI, Kandimalla R, Paraskevas G, Kern S, Kirsebom BS, Kornhuber J, Lagarde J, Landau SM, Legdeur N, Llibre Guerra JJ, Maserejian NN, Marquie M, Minatani S, Morbelli SD, Mroczko B, Ntanasi E, de Oliveira CR, Olivieri P, Orellana A, Perrin RJ, Peters O, Prabhakar S, Ramakers IH, Rodriguez-Rodriguez E, Ruiz A, Ruther E, Selnes P, Silva D, Soininen H, Spiru L, Takeda A, Teichmann M, Tijms BM, Teunissen CE, Thompson LI, Vogelgsangs J, Voglein J, Waldemar G, Wallin AK, Yannakoulia M, Yi D, Zettergren A. Depressive Symptoms and Amyloid Pathology. JAMA Psychiatry. 2025;82(3):296-310. doi: 10.1001/jamapsychiatry.2024.4305. PubMed PMID: 39841452; PMCID: PMC11883504. 

Zamani J, Vahid A, Avelar-Pereira B, Gozdas E, Hosseini SMH, Alzheimer’s Disease Neuroimaging I. Mapping amyloid beta predictors of entorhinal tau in preclinical Alzheimer’s disease. Alzheimers Dement. 2025;21(2):e14499. Epub 20250108. doi: 10.1002/alz.14499. PubMed PMID: 39777850; PMCID: PMC11848422. 

2024

Arnold SE, Hyman BT, Betensky RA, Dodge HH. Pathways to personalized medicine-Embracing heterogeneity for progress in clinical therapeutics research in Alzheimer’s disease. Alzheimers Dement. 2024;20(10):7384-94. Epub 20240906. doi: 10.1002/alz.14063. PubMed PMID: 39240044; PMCID: PMC11485305. 

Bonomi S, Lu R, Schindler SE, Bui Q, Lah JJ, Wolk D, Gleason CE, Sperling R, Roberson ED, Levey AI, Shaw L, Van Hulle C, Benzinger T, Adams M, Manzanares C, Qiu D, Hassenstab J, Moulder KL, Balls-Berry JE, Johnson K, Johnson SC, Murchison CF, Luo J, Gremminger E, Agboola F, Grant EA, Hornbeck R, Massoumzadeh P, Keefe S, Dierker D, Gray J, Henson RL, Streitz M, Mechanic-Hamilton D, Morris JC, Xiong C. Relationships of Cognitive Measures with Cerebrospinal Fluid but Not Imaging Biomarkers of Alzheimer Disease Vary between Black and White Individuals. Ann Neurol. 2024;95(3):495-506. Epub 20231219. doi: 10.1002/ana.26838. PubMed PMID: 38038976; PMCID: PMC10922199. 

Boyle R, Townsend DL, Klinger HM, Scanlon CE, Yuan Z, Coughlan GT, Seto M, Shirzadi Z, Yau WW, Jutten RJ, Schneider C, Farrell ME, Hanseeuw BJ, Mormino EC, Yang HS, Papp KV, Amariglio RE, Jacobs HIL, Price JC, Chhatwal JP, Schultz AP, Properzi MJ, Rentz DM, Johnson KA, Sperling RA, Hohman TJ, Donohue MC, Buckley RF, Alzheimer’s Disease Neuroimaging I. Identifying longitudinal cognitive resilience from cross-sectional amyloid, tau, and neurodegeneration. Alzheimers Res Ther. 2024;16(1):148. Epub 20240703. doi: 10.1186/s13195-024-01510-y. PubMed PMID: 38961512; PMCID: PMC11220971. 

Bueicheku E, Diez I, Kim CM, Becker JA, Koops EA, Kwong K, Papp KV, Salat DH, Bennett DA, Rentz DM, Sperling RA, Johnson KA, Sepulcre J, Jacobs HIL. Spatiotemporal patterns of locus coeruleus integrity predict cortical tau and cognition. Nat Aging. 2024;4(5):625-37. Epub 20240425. doi: 10.1038/s43587-024-00626-y. PubMed PMID: 38664576; PMCID: PMC11108787. 

Burling JE, Katz Z, Yuan Z, Munro C, Mimmack K, Ma G, Hanseeuw BJ, Papp KV, Amariglio RE, Vannini P, Rentz DM, Quiroz YT, Johnson KA, Sperling RA, Blacker D, Marshall GA, Yang HS, Gatchel JR. Study Partner Report of Apathy in Older Adults is Associated with AD Biomarkers: Findings from the Harvard Aging Brain Study. Am J Geriatr Psychiatry. 2024;32(8):909-19. Epub 20240128. doi: 10.1016/j.jagp.2024.01.020. PubMed PMID: 38443298. 

Diez I, Ortiz-Teran L, Ng TSC, Albers MW, Marshall G, Orwig W, Kim CM, Bueicheku E, Montal V, Olofsson J, Vannini P, El Fahkri G, Sperling R, Johnson K, Jacobs HIL, Sepulcre J. Tau propagation in the brain olfactory circuits is associated with smell perception changes in aging. Nat Commun. 2024;15(1):4809. Epub 20240606. doi: 10.1038/s41467-024-48462-3. PubMed PMID: 38844444; PMCID: PMC11156945. 

Dubbelman MA, Diez I, Gonzalez C, Amariglio RE, Becker JA, Chhatwal JP, Gatchel JR, Johnson KA, Locascio JJ, Udeogu OJ, Wang S, Papp KV, Properzi MJ, Rentz DM, Schultz AP, Sperling RA, Vannini P, Marshall GA. Amyloid and tau burden relate to longitudinal changes in the performance of complex everyday activities among cognitively unimpaired older adults: results from the performance-based Harvard Automated Phone Task. Front Aging Neurosci. 2024;16:1420290. Epub 20240612. doi: 10.3389/fnagi.2024.1420290. PubMed PMID: 38934017; PMCID: PMC11199537. 

Engels-Dominguez N, Koops EA, Hsieh S, Wiklund EE, Schultz AP, Riphagen JM, Prokopiou PC, Hanseeuw BJ, Rentz DM, Sperling RA, Johnson KA, Jacobs HIL. Lower in vivo locus coeruleus integrity is associated with lower cortical thickness in older individuals with elevated Alzheimer’s pathology: a cohort study. Alzheimers Res Ther. 2024;16(1):129. Epub 20240617. doi: 10.1186/s13195-024-01500-0. PubMed PMID: 38886798; PMCID: PMC11181564. 

Engels-Dominguez N, Riphagen JM, Van Egroo M, Koops EA, Smegal LF, Becker JA, Prokopiou PC, Bueicheku E, Kwong KK, Rentz DM, Salat DH, Sperling RA, Johnson KA, Jacobs HIL. Lower Locus Coeruleus Integrity Signals Elevated Entorhinal Tau and Clinical Progression in Asymptomatic Older Individuals. Ann Neurol. 2024;96(4):650-61. Epub 20240715. doi: 10.1002/ana.27022. PubMed PMID: 39007398; PMCID: PMC11534559. 

Farrell ME, Thibault EG, Becker JA, Price JC, Healy BC, Hanseeuw BJ, Buckley RF, Jacobs HIL, Schultz AP, Chen CD, Sperling RA, Johnson KA. Spatial extent as a sensitive amyloid-PET metric in preclinical Alzheimer’s disease. Alzheimers Dement. 2024;20(8):5434-49. Epub 20240710. doi: 10.1002/alz.14036. PubMed PMID: 38988055; PMCID: PMC11350060. 

Gong K, Johnson K, El Fakhri G, Li Q, Pan T. PET image denoising based on denoising diffusion probabilistic model. Eur J Nucl Med Mol Imaging. 2024;51(2):358-68. Epub 20231003. doi: 10.1007/s00259-023-06417-8. PubMed PMID: 37787849; PMCID: PMC10958486. 

Jadick MF, Robinson T, Farrell ME, Klinger H, Buckley RF, Marshall GA, Vannini P, Rentz DM, Johnson KA, Sperling RA, Amariglio RE. Associations Between Self and Study Partner Report of Cognitive Decline With Regional Tau in a Multicohort Study. Neurology. 2024;102(12):e209447. Epub 20240529. doi: 10.1212/WNL.0000000000209447. PubMed PMID: 38810211; PMCID: PMC11226320. 

Jutten RJ, Amariglio RE, Maruff P, Properzi MJ, Rentz DM, Johnson KA, Sperling RA, Papp KV. Increased intraindividual variability in reaction time performance is associated with emerging cognitive decline in cognitively unimpaired adults. Neuropsychology. 2024;38(2):184-97. Epub 20231116. doi: 10.1037/neu0000928. PubMed PMID: 37971861. 

Kang K, Seidlitz J, Bethlehem RAI, Xiong J, Jones MT, Mehta K, Keller AS, Tao R, Randolph A, Larsen B, Tervo-Clemmens B, Feczko E, Miranda Dominguez O, Nelson S, Lifespan Brain Chart C, R B, Aibl, Alzheimer’s Disease Neuroimaging I, Alzheimer’s Disease Repository Without Borders I, Team C, Ccnp, Cobre, cVeda, Harvard Aging Brain S, Imagen, Pond, Group P-AR, Schildcrout J, Fair D, Satterthwaite TD, Alexander-Bloch A, Vandekar S. Study design features increase replicability in cross-sectional and longitudinal brain-wide association studies. bioRxiv. 2024. Epub 20240624. doi: 10.1101/2023.05.29.542742. PubMed PMID: 37398345; PMCID: PMC10312450. 

Khasnavis S, O’Dell RS, van Dyck CH, Mecca AP. Commentary on “Study Partner Report of Apathy in Older Adults is Associated With AD Biomarkers: Findings From the Harvard Aging Brain Study”. Am J Geriatr Psychiatry. 2024;32(8):920-1. Epub 20240404. doi: 10.1016/j.jagp.2024.03.017. PubMed PMID: 38658231. 

Klinger HM, Healy BC, Hanseeuw BJ, Jones RN, Boyle R, Townsend DL, Properzi MJ, Coughlan GT, Seto M, Birkenbihl C, Farrell ME, Papp KV, Chhatwal JP, Yang HS, Schultz AP, Amariglio RE, Jacobs HIL, Price JC, Johnson KA, Rentz DM, Sperling RA, Buckley RF. Latent change-on-change between amyloid accumulation and cognitive decline. Alzheimers Dement. 2024;20(12):8728-38. Epub 20241029. doi: 10.1002/alz.14326. PubMed PMID: 39470175; PMCID: PMC11667500. 

Lee H, Fu JF, Gaudet K, Bryant AG, Price JC, Bennett RE, Johnson KA, Hyman BT, Hedden T, Salat DH, Yen YF, Huang SY. Aberrant vascular architecture in the hippocampus correlates with tau burden in mild cognitive impairment and Alzheimer’s disease. J Cereb Blood Flow Metab. 2024;44(5):787-800. Epub 20231124. doi: 10.1177/0271678X231216144. PubMed PMID: 38000018; PMCID: PMC11197134. 

Liu X, Marin T, Vafay Eslahi S, Tiss A, Chemli Y, Johson KA, El Fakhri G, Ouyang J. Subject-aware PET Denoising with Contrastive Adversarial Domain Generalization. IEEE Nucl Sci Symp Conf Rec (1997). 2024;2024. Epub 20240925. doi: 10.1109/nss/mic/rtsd57108.2024.10656150. PubMed PMID: 39445307; PMCID: PMC11497478. 

Liu X, Vafay Eslahi S, Marin T, Tiss A, Chemli Y, Huang Y, Johnson KA, El Fakhri G, Ouyang J. Cross noise level PET denoising with continuous adversarial domain generalization. Phys Med Biol. 2024;69(8). Epub 20240403. doi: 10.1088/1361-6560/ad341a. PubMed PMID: 38484401; PMCID: PMC11195012. 

Mather MA, Ho EH, Bedjeti K, Karpouzian-Rogers T, Rogalski EJ, Gershon R, Weintraub S. Measuring Multidimensional Aspects of Health in the Oldest Old Using the NIH Toolbox: Results From the ARMADA Study. Arch Clin Neuropsychol. 2024;39(5):535-46. doi: 10.1093/arclin/acad105. PubMed PMID: 38216151; PMCID: PMC11269891. 

Munro CE, Farrell M, Hanseeuw B, Rentz DM, Buckley R, Properzi M, Yuan Z, Vannini P, Amariglio RE, Quiroz YT, Blacker D, Sperling RA, Johnson KA, Marshall GA, Gatchel JR. Change in Depressive Symptoms and Longitudinal Regional Amyloid Accumulation in Unimpaired Older Adults. JAMA Netw Open. 2024;7(8):e2427248. Epub 20240801. doi: 10.1001/jamanetworkopen.2024.27248. PubMed PMID: 39207757; PMCID: PMC11362871. 

Pahl J, Prokopiou PC, Bueicheku E, Schultz AP, Papp KV, Farrell ME, Rentz DM, Sperling RA, Johnson KA, Jacobs HIL. Locus coeruleus integrity and left frontoparietal connectivity provide resilience against attentional decline in preclinical alzheimer’s disease. Alzheimers Res Ther. 2024;16(1):119. Epub 20240531. doi: 10.1186/s13195-024-01485-w. PubMed PMID: 38822365; PMCID: PMC11140954. 

Papp KV, Jutten RJ, Soberanes D, Weizenbaum E, Hsieh S, Molinare C, Buckley R, Betensky RA, Marshall GA, Johnson KA, Rentz DM, Sperling R, Amariglio RE. Early Detection of Amyloid-Related Changes in Memory among Cognitively Unimpaired Older Adults with Daily Digital Testing. Ann Neurol. 2024;95(3):507-17. Epub 20231219. doi: 10.1002/ana.26833. PubMed PMID: 37991080; PMCID: PMC10922126. 

Schneider C, Prokopiou PC, Papp KV, Engels-Dominguez N, Hsieh S, Juneau TA, Schultz AP, Rentz DM, Sperling RA, Johnson KA, Jacobs HIL. Atrophy links lower novelty-related locus coeruleus connectivity to cognitive decline in preclinical AD. Alzheimers Dement. 2024;20(6):3958-71. Epub 20240427. doi: 10.1002/alz.13839. PubMed PMID: 38676563; PMCID: PMC11180940. 

Scott MR, Edwards NC, Properzi MJ, Jacobs HI, Price JC, Lois C, Farrell ME, Hanseeuw BJ, Thibault EG, Rentz DM, Johnson KA, Sperling RA, Schultz AP, Buckley RF. Contribution of extracerebral tracer retention and partial volume effects to sex differences in Flortaucipir-PET signal. J Cereb Blood Flow Metab. 2024;44(1):131-41. Epub 20230920. doi: 10.1177/0271678X231196978. PubMed PMID: 37728659; PMCID: PMC10905641. 

Shirzadi Z, Boyle R, Yau WW, Coughlan G, Fu JF, Properzi MJ, Buckley RF, Yang HS, Scanlon CE, Hsieh S, Amariglio RE, Papp K, Rentz D, Price JC, Johnson KA, Sperling RA, Chhatwal JP, Schultz AP. Vascular contributions to cognitive decline: Beyond amyloid and tau in the Harvard Aging Brain Study. J Cereb Blood Flow Metab. 2024;44(8):1319-28. Epub 20240307. doi: 10.1177/0271678X241237624. PubMed PMID: 38452039; PMCID: PMC11342726. 

Shirzadi Z, Schultz AP, Properzi M, Yaari R, Yau WW, Brickman AM, Rafii MS, Donohue MC, Ernstrom K, Wang S, Jack CR, Jr., Greenberg SM, Raman R, Aisen P, Sperling RA, Chhatwal JP. Greater White Matter Hyperintensity Volume Is Associated with the Number of Microhemorrhages in Preclinical Alzheimer’s Disease. J Prev Alzheimers Dis. 2024;11(4):869-73. doi: 10.14283/jpad.2024.139. PubMed PMID: 39044495; PMCID: PMC11266366. 

Stankeviciute L, Chhatwal JP, Levin R, Pinilla V, Schultz AP, Redline S, Johnson KA, Sperling RA, Kozhemiako N, Purcell S, Djonlagic I. Amyloid beta-independent sleep markers associated with early regional tau burden and cortical thinning. Alzheimers Dement (Amst). 2024;16(3):e12616. Epub 20240729. doi: 10.1002/dad2.12616. PubMed PMID: 39077684; PMCID: PMC11284643. 

Weizenbaum EL, Soberanes D, Hsieh S, Molinare CP, Buckley RF, Betensky RA, Properzi MJ, Marshall GA, Rentz DM, Johnson KA, Sperling RA, Amariglio RE, Papp KV. Capturing learning curves with the multiday Boston Remote Assessment of Neurocognitive Health (BRANCH): Feasibility, reliability, and validity. Neuropsychology. 2024;38(2):198-210. Epub 20231116. doi: 10.1037/neu0000933. PubMed PMID: 37971862; PMCID: PMC10841660. 

Yang HS, Yau WW, Carlyle BC, Trombetta BA, Zhang C, Shirzadi Z, Schultz AP, Pruzin JJ, Fitzpatrick CD, Kirn DR, Rabin JS, Buckley RF, Hohman TJ, Rentz DM, Tanzi RE, Johnson KA, Sperling RA, Arnold SE, Chhatwal JP. Plasma VEGFA and PGF impact longitudinal tau and cognition in preclinical Alzheimer’s disease. Brain. 2024;147(6):2158-68. doi: 10.1093/brain/awae034. PubMed PMID: 38315899; PMCID: PMC11146430. 

Zhang H, Cao P, Mak HKF, Hui ES. The structural-functional-connectivity coupling of the aging brain. Geroscience. 2024;46(4):3875-87. Epub 20240306. doi: 10.1007/s11357-024-01106-2. PubMed PMID: 38443539; PMCID: PMC11226573. 

2023

Costoya-Sanchez A, Moscoso A, Silva-Rodriguez J, Pontecorvo MJ, Devous MD, Sr., Aguiar P, Scholl M, Grothe MJ, Alzheimer’s Disease Neuroimaging I, the Harvard Aging Brain S. Increased Medial Temporal Tau Positron Emission Tomography Uptake in the Absence of Amyloid-beta Positivity. JAMA Neurol. 2023;80(10):1051-61. doi: 10.1001/jamaneurol.2023.2560. PubMed PMID: 37578787; PMCID: PMC10425864. 

Gagliardi G, Rodriguez-Vieitez E, Montal V, Sepulcre J, Diez I, Lois C, Hanseeuw B, Schultz AP, Properzi MJ, Papp KV, Marshall GA, Fortea J, Johnson KA, Sperling RA, Vannini P. Cortical microstructural changes predict tau accumulation and episodic memory decline in older adults harboring amyloid. Commun Med (Lond). 2023;3(1):106. Epub 20230801. doi: 10.1038/s43856-023-00324-7. PubMed PMID: 37528163; PMCID: PMC10394044. 

Hampton OL, Mukherjee S, Properzi MJ, Schultz AP, Crane PK, Gibbons LE, Hohman TJ, Maruff P, Lim YY, Amariglio RE, Papp KV, Johnson KA, Rentz DM, Sperling RA, Buckley RF. Harmonizing the preclinical Alzheimer cognitive composite for multicohort studies. Neuropsychology. 2023;37(4):436-49. Epub 20220721. doi: 10.1037/neu0000833. PubMed PMID: 35862098; PMCID: PMC9859944. 

Hanseeuw BJ, Jacobs HIL, Schultz AP, Buckley RF, Farrell ME, Guehl NJ, Becker JA, Properzi M, Sanchez JS, Quiroz YT, Vannini P, Sepulcre J, Yang HS, Chhatwal JP, Gatchel J, Marshall GA, Amariglio R, Papp K, Rentz DM, Normandin M, Price JC, Healy BC, El Fakhri G, Sperling RA, Johnson KA. Association of Pathologic and Volumetric Biomarker Changes With Cognitive Decline in Clinically Normal Adults. Neurology. 2023;101(24):e2533-e44. Epub 20231108. doi: 10.1212/WNL.0000000000207962. PubMed PMID: 37968130; PMCID: PMC10791053. 

Insel PS, Young CB, Aisen PS, Johnson KA, Sperling RA, Mormino EC, Donohue MC. Tau positron emission tomography in preclinical Alzheimer’s disease. Brain. 2023;146(2):700-11. doi: 10.1093/brain/awac299. PubMed PMID: 35962782; PMCID: PMC10169284. 

Jacobs HIL, Becker JA, Kwong K, Munera D, Ramirez-Gomez L, Engels-Dominguez N, Sanchez JS, Vila-Castelar C, Baena A, Sperling RA, Johnson KA, Lopera F, Quiroz YT. Waning locus coeruleus integrity precedes cortical tau accrual in preclinical autosomal dominant Alzheimer’s disease. Alzheimers Dement. 2023;19(1):169-80. Epub 20220317. doi: 10.1002/alz.12656. PubMed PMID: 35298083; PMCID: PMC9481982. 

Karpouzian-Rogers T, Ho E, Novack M, Chinkers M, Bedjeti K, Nowinski C, Giordani B, Gershon R, Weintraub S. Baseline characterization of the ARMADA (Assessing Reliable Measurement in Alzheimer’s Disease) study cohorts. Alzheimers Dement. 2023;19(5):1974-82. Epub 20221117. doi: 10.1002/alz.12816. PubMed PMID: 36396612; PMCID: PMC10182183. 

Nguyen Ho PT, van Arendonk J, Steketee RME, van Rooij FJA, Roshchupkin GV, Ikram MA, Vernooij MW, Neitzel J. Predicting amyloid-beta pathology in the general population. Alzheimers Dement. 2023;19(12):5506-17. Epub 20230611. doi: 10.1002/alz.13161. PubMed PMID: 37303116; PMCID: PMC7616996. 

Rentz DM, Klinger HM, Samaroo A, Fitzpatrick C, Schneider OR, Amagai S, Peipert JD. Face Name Associative Memory Exam and biomarker status in the ARMADA study: Advancing reliable measurement in Alzheimer’s disease and cognitive aging. Alzheimers Dement (Amst). 2023;15(3):e12473. Epub 20230907. doi: 10.1002/dad2.12473. PubMed PMID: 37693224; PMCID: PMC10483494. 

Shirzadi Z, Rabin J, Launer LJ, Bryan RN, Al-Ozairi A, Chhatwal J, Al-Ozairi E, Detre JA, Black SE, Swardfager W, MacIntosh BJ. Metabolic and Vascular Risk Factor Variability Over 25 Years Relates to Midlife Brain Volume and Cognition. J Alzheimers Dis. 2023;91(2):627-35. doi: 10.3233/JAD-220340. PubMed PMID: 36683514; PMCID: PMC11004795. 

Shirzadi Z, Schultz SA, Yau WW, Joseph-Mathurin N, Fitzpatrick CD, Levin R, Kantarci K, Preboske GM, Jack CR, Jr., Farlow MR, Hassenstab J, Jucker M, Morris JC, Xiong C, Karch CM, Levey AI, Gordon BA, Schofield PR, Salloway SP, Perrin RJ, McDade E, Levin J, Cruchaga C, Allegri RF, Fox NC, Goate A, Day GS, Koeppe R, Chui HC, Berman S, Mori H, Sanchez-Valle R, Lee JH, Rosa-Neto P, Ruthirakuhan M, Wu CY, Swardfager W, Benzinger TLS, Sohrabi HR, Martins RN, Bateman RJ, Johnson KA, Sperling RA, Greenberg SM, Schultz AP, Chhatwal JP, Dominantly Inherited Alzheimer N, the Alzheimer’s Disease Neuroimaging I. Etiology of White Matter Hyperintensities in Autosomal Dominant and Sporadic Alzheimer Disease. JAMA Neurol. 2023;80(12):1353-63. doi: 10.1001/jamaneurol.2023.3618. PubMed PMID: 37843849; PMCID: PMC10580156. 

Tosun D, Thropp P, Southekal S, Spottiswoode B, Fahmi R, Alzheimer’s Disease Neuroimaging I. Profiling and predicting distinct tau progression patterns: An unsupervised data-driven approach to flortaucipir positron emission tomography. Alzheimers Dement. 2023;19(12):5605-19. Epub 20230608. doi: 10.1002/alz.13164. PubMed PMID: 37288753; PMCID: PMC10704003. 

Zhang W, Wang HF, Kuo K, Wang L, Li Y, Yu J, Feng J, Cheng W. Contribution of Alzheimer’s disease pathology to biological and clinical progression: A longitudinal study across two cohorts. Alzheimers Dement. 2023;19(8):3602-12. Epub 20230225. doi: 10.1002/alz.12992. PubMed PMID: 36840615. 

2022

Bethlehem RAI, Seidlitz J, White SR, Vogel JW, Anderson KM, Adamson C, Adler S, Alexopoulos GS, Anagnostou E, Areces-Gonzalez A, Astle DE, Auyeung B, Ayub M, Bae J, Ball G, Baron-Cohen S, Beare R, Bedford SA, Benegal V, Beyer F, Blangero J, Blesa Cabez M, Boardman JP, Borzage M, Bosch-Bayard JF, Bourke N, Calhoun VD, Chakravarty MM, Chen C, Chertavian C, Chetelat G, Chong YS, Cole JH, Corvin A, Costantino M, Courchesne E, Crivello F, Cropley VL, Crosbie J, Crossley N, Delarue M, Delorme R, Desrivieres S, Devenyi GA, Di Biase MA, Dolan R, Donald KA, Donohoe G, Dunlop K, Edwards AD, Elison JT, Ellis CT, Elman JA, Eyler L, Fair DA, Feczko E, Fletcher PC, Fonagy P, Franz CE, Galan-Garcia L, Gholipour A, Giedd J, Gilmore JH, Glahn DC, Goodyer IM, Grant PE, Groenewold NA, Gunning FM, Gur RE, Gur RC, Hammill CF, Hansson O, Hedden T, Heinz A, Henson RN, Heuer K, Hoare J, Holla B, Holmes AJ, Holt R, Huang H, Im K, Ipser J, Jack CR, Jr., Jackowski AP, Jia T, Johnson KA, Jones PB, Jones DT, Kahn RS, Karlsson H, Karlsson L, Kawashima R, Kelley EA, Kern S, Kim KW, Kitzbichler MG, Kremen WS, Lalonde F, Landeau B, Lee S, Lerch J, Lewis JD, Li J, Liao W, Liston C, Lombardo MV, Lv J, Lynch C, Mallard TT, Marcelis M, Markello RD, Mathias SR, Mazoyer B, McGuire P, Meaney MJ, Mechelli A, Medic N, Misic B, Morgan SE, Mothersill D, Nigg J, Ong MQW, Ortinau C, Ossenkoppele R, Ouyang M, Palaniyappan L, Paly L, Pan PM, Pantelis C, Park MM, Paus T, Pausova Z, Paz-Linares D, Pichet Binette A, Pierce K, Qian X, Qiu J, Qiu A, Raznahan A, Rittman T, Rodrigue A, Rollins CK, Romero-Garcia R, Ronan L, Rosenberg MD, Rowitch DH, Salum GA, Satterthwaite TD, Schaare HL, Schachar RJ, Schultz AP, Schumann G, Scholl M, Sharp D, Shinohara RT, Skoog I, Smyser CD, Sperling RA, Stein DJ, Stolicyn A, Suckling J, Sullivan G, Taki Y, Thyreau B, Toro R, Traut N, Tsvetanov KA, Turk-Browne NB, Tuulari JJ, Tzourio C, Vachon-Presseau E, Valdes-Sosa MJ, Valdes-Sosa PA, Valk SL, van Amelsvoort T, Vandekar SN, Vasung L, Victoria LW, Villeneuve S, Villringer A, Vertes PE, Wagstyl K, Wang YS, Warfield SK, Warrier V, Westman E, Westwater ML, Whalley HC, Witte AV, Yang N, Yeo B, Yun H, Zalesky A, Zar HJ, Zettergren A, Zhou JH, Ziauddeen H, Zugman A, Zuo XN, R B, Aibl, Alzheimer’s Disease Neuroimaging I, Alzheimer’s Disease Repository Without Borders I, Team C, Cam CAN, Ccnp, Cobre, cVeda, Group EDBAW, Developing Human Connectome P, FinnBrain, Harvard Aging Brain S, Imagen, Kne, Mayo Clinic Study of A, Nspn, Pond, Group P-AR, Vetsa, Bullmore ET, Alexander-Bloch AF. Publisher Correction: Brain charts for the human lifespan. Nature. 2022;610(7931):E6. doi: 10.1038/s41586-022-05300-0. PubMed PMID: 36151472; PMCID: PMC9556297. 

Farrell ME, Papp KV, Buckley RF, Jacobs HIL, Schultz AP, Properzi MJ, Vannini P, Hanseeuw BJ, Rentz DM, Johnson KA, Sperling RA. Association of Emerging beta-Amyloid and Tau Pathology With Early Cognitive Changes in Clinically Normal Older Adults. Neurology. 2022;98(15):e1512-e24. Epub 20220325. doi: 10.1212/WNL.0000000000200137. PubMed PMID: 35338074; PMCID: PMC9012271. 

Grober E, Lipton RB, Sperling RA, Papp KV, Johnson KA, Rentz DM, Veroff AE, Aisen PS, Ezzati A. Associations of Stages of Objective Memory Impairment With Amyloid PET and Structural MRI: The A4 Study. Neurology. 2022;98(13):e1327-e36. Epub 20220223. doi: 10.1212/WNL.0000000000200046. PubMed PMID: 35197359; PMCID: PMC8967421. 

Hansson O, Edelmayer RM, Boxer AL, Carrillo MC, Mielke MM, Rabinovici GD, Salloway S, Sperling R, Zetterberg H, Teunissen CE. The Alzheimer’s Association appropriate use recommendations for blood biomarkers in Alzheimer’s disease. Alzheimers Dement. 2022;18(12):2669-86. Epub 20220731. doi: 10.1002/alz.12756. PubMed PMID: 35908251; PMCID: PMC10087669. 

Jansen WJ, Janssen O, Tijms BM, Vos SJB, Ossenkoppele R, Visser PJ, Amyloid Biomarker Study G, Aarsland D, Alcolea D, Altomare D, von Arnim C, Baiardi S, Baldeiras I, Barthel H, Bateman RJ, Van Berckel B, Binette AP, Blennow K, Boada M, Boecker H, Bottlaender M, den Braber A, Brooks DJ, Van Buchem MA, Camus V, Carill JM, Cerman J, Chen K, Chetelat G, Chipi E, Cohen AD, Daniels A, Delarue M, Didic M, Drzezga A, Dubois B, Eckerstrom M, Ekblad LL, Engelborghs S, Epelbaum S, Fagan AM, Fan Y, Fladby T, Fleisher AS, Van der Flier WM, Forster S, Fortea J, Frederiksen KS, Freund-Levi Y, Frings L, Frisoni GB, Frohlich L, Gabryelewicz T, Gertz HJ, Gill KD, Gkatzima O, Gomez-Tortosa E, Grimmer T, Guedj E, Habeck CG, Hampel H, Handels R, Hansson O, Hausner L, Hellwig S, Heneka MT, Herukka SK, Hildebrandt H, Hodges J, Hort J, Huang CC, Iriondo AJ, Itoh Y, Ivanoiu A, Jagust WJ, Jessen F, Johannsen P, Johnson KA, Kandimalla R, Kapaki EN, Kern S, Kilander L, Klimkowicz-Mrowiec A, Klunk WE, Koglin N, Kornhuber J, Kramberger MG, Kuo HC, Van Laere K, Landau SM, Landeau B, Lee DY, de Leon M, Leyton CE, Lin KJ, Lleo A, Lowenmark M, Madsen K, Maier W, Marcusson J, Marquie M, Martinez-Lage P, Maserejian N, Mattsson N, de Mendonca A, Meyer PT, Miller BL, Minatani S, Mintun MA, Mok VCT, Molinuevo JL, Morbelli SD, Morris JC, Mroczko B, Na DL, Newberg A, Nobili F, Nordberg A, Olde Rikkert MGM, de Oliveira CR, Olivieri P, Orellana A, Paraskevas G, Parchi P, Pardini M, Parnetti L, Peters O, Poirier J, Popp J, Prabhakar S, Rabinovici GD, Ramakers IH, Rami L, Reiman EM, Rinne JO, Rodrigue KM, Rodriguez-Rodriguez E, Roe CM, Rosa-Neto P, Rosen HJ, Rot U, Rowe CC, Ruther E, Ruiz A, Sabri O, Sakhardande J, Sanchez-Juan P, Sando SB, Santana I, Sarazin M, Scheltens P, Schroder J, Selnes P, Seo SW, Silva D, Skoog I, Snyder PJ, Soininen H, Sollberger M, Sperling RA, Spiru L, Stern Y, Stomrud E, Takeda A, Teichmann M, Teunissen CE, Thompson LI, Tomassen J, Tsolaki M, Vandenberghe R, Verbeek MM, Verhey FRJ, Villemagne V, Villeneuve S, Vogelgsang J, Waldemar G, Wallin A, Wallin AK, Wiltfang J, Wolk DA, Yen TC, Zboch M, Zetterberg H. Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum. JAMA Neurol. 2022;79(3):228-43. doi: 10.1001/jamaneurol.2021.5216. PubMed PMID: 35099509. 

Montal V, Diez I, Kim CM, Orwig W, Bueicheku E, Gutierrez-Zuniga R, Bejanin A, Pegueroles J, Dols-Icardo O, Vannini P, El-Fakhri G, Johnson KA, Sperling RA, Fortea J, Sepulcre J. Network Tau spreading is vulnerable to the expression gradients of APOE and glutamatergic-related genes. Sci Transl Med. 2022;14(655):eabn7273. Epub 20220727. doi: 10.1126/scitranslmed.abn7273. PubMed PMID: 35895837; PMCID: PMC9942690. 

Ossenkoppele R, Pichet Binette A, Groot C, Smith R, Strandberg O, Palmqvist S, Stomrud E, Tideman P, Ohlsson T, Jogi J, Johnson K, Sperling R, Dore V, Masters CL, Rowe C, Visser D, van Berckel BNM, van der Flier WM, Baker S, Jagust WJ, Wiste HJ, Petersen RC, Jack CR, Jr., Hansson O. Amyloid and tau PET-positive cognitively unimpaired individuals are at high risk for future cognitive decline. Nat Med. 2022;28(11):2381-7. Epub 20221110. doi: 10.1038/s41591-022-02049-x. PubMed PMID: 36357681; PMCID: PMC9671808. 

Ozlen H, Pichet Binette A, Kobe T, Meyer PF, Gonneaud J, St-Onge F, Provost K, Soucy JP, Rosa-Neto P, Breitner J, Poirier J, Villeneuve S, Alzheimer’s Disease Neuroimaging Initiative tHABStPEoEoNTfADRG. Spatial Extent of Amyloid-beta Levels and Associations With Tau-PET and Cognition. JAMA Neurol. 2022;79(10):1025-35. doi: 10.1001/jamaneurol.2022.2442. PubMed PMID: 35994280; PMCID: PMC9396472. 

Prokopiou PC, Engels-Dominguez N, Papp KV, Scott MR, Schultz AP, Schneider C, Farrell ME, Buckley RF, Quiroz YT, El Fakhri G, Rentz DM, Sperling RA, Johnson KA, Jacobs HIL. Lower novelty-related locus coeruleus function is associated with Abeta-related cognitive decline in clinically healthy individuals. Nat Commun. 2022;13(1):1571. Epub 20220323. doi: 10.1038/s41467-022-28986-2. PubMed PMID: 35322012; PMCID: PMC8943159. 

Pruzin JJ, Klein H, Rabin JS, Schultz AP, Kirn DR, Yang HS, Buckley RF, Scott MR, Properzi M, Rentz DM, Johnson KA, Sperling RA, Chhatwal JP. Physical activity is associated with increased resting-state functional connectivity in networks predictive of cognitive decline in clinically unimpaired older adults. Alzheimers Dement (Amst). 2022;14(1):e12319. Epub 20220707. doi: 10.1002/dad2.12319. PubMed PMID: 35821672; PMCID: PMC9261733. 

Rabin JS, Pruzin J, Scott M, Yang HS, Hampton O, Hsieh S, Schultz AP, Buckley RF, Hedden T, Rentz D, Johnson KA, Sperling RA, Chhatwal JP. Association of beta-Amyloid and Vascular Risk on Longitudinal Patterns of Brain Atrophy. Neurology. 2022;99(3):e270-e80. Epub 20220718. doi: 10.1212/WNL.0000000000200551. PubMed PMID: 35473760; PMCID: PMC9302937. 

Strikwerda-Brown C, Hobbs DA, Gonneaud J, St-Onge F, Binette AP, Ozlen H, Provost K, Soucy JP, Buckley RF, Benzinger TLS, Morris JC, Villemagne VL, Dore V, Sperling RA, Johnson KA, Rowe CC, Gordon BA, Poirier J, Breitner JCS, Villeneuve S, Prevent-Ad H, Groups AR. Association of Elevated Amyloid and Tau Positron Emission Tomography Signal With Near-Term Development of Alzheimer Disease Symptoms in Older Adults Without Cognitive Impairment. JAMA Neurol. 2022;79(10):975-85. doi: 10.1001/jamaneurol.2022.2379. PubMed PMID: 35907254; PMCID: PMC9339146. 

Willey B, Mimmack K, Gagliardi G, Dossett ML, Wang S, Udeogu OJ, Donovan NJ, Gatchel JR, Quiroz YT, Amariglio R, Liu CH, Hyun S, ElTohamy A, Rentz D, Sperling RA, Marshall GA, Vannini P. Racial and socioeconomic status differences in stress, posttraumatic growth, and mental health in an older adult cohort during the COVID-19 pandemic. EClinicalMedicine. 2022;45:101343. Epub 20220313. doi: 10.1016/j.eclinm.2022.101343. PubMed PMID: 35291556; PMCID: PMC8917957. 

Yang HS, Zhang C, Carlyle BC, Zhen SY, Trombetta BA, Schultz AP, Pruzin JJ, Fitzpatrick CD, Yau WW, Kirn DR, Rentz DM, Arnold SE, Johnson KA, Sperling RA, Chhatwal JP, Tanzi RE. Plasma IL-12/IFN-gamma axis predicts cognitive trajectories in cognitively unimpaired older adults. Alzheimers Dement. 2022;18(4):645-53. Epub 20210623. doi: 10.1002/alz.12399. PubMed PMID: 34160128; PMCID: PMC8695625. 

Yau WW, Shirzadi Z, Yang HS, Ikoba AP, Rabin JS, Properzi MJ, Kirn DR, Schultz AP, Rentz DM, Johnson KA, Sperling RA, Chhatwal JP. Tau Mediates Synergistic Influence of Vascular Risk and Abeta on Cognitive Decline. Ann Neurol. 2022;92(5):745-55. Epub 20220813. doi: 10.1002/ana.26460. PubMed PMID: 35880989; PMCID: PMC9650958. 

Young CB, Winer JR, Younes K, Cody KA, Betthauser TJ, Johnson SC, Schultz A, Sperling RA, Greicius MD, Cobos I, Poston KL, Mormino EC, Alzheimer’s Disease Neuroimaging I, the Harvard Aging Brain S. Divergent Cortical Tau Positron Emission Tomography Patterns Among Patients With Preclinical Alzheimer Disease. JAMA Neurol. 2022;79(6):592-603. doi: 10.1001/jamaneurol.2022.0676. PubMed PMID: 35435938; PMCID: PMC9016616. 

2021

Belloy ME, Eger SJ, Le Guen Y, Napolioni V, Deters KD, Yang HS, Scelsi MA, Porter T, James SN, Wong A, Schott JM, Sperling RA, Laws SM, Mormino EC, He Z, Han SS, Altmann A, Greicius MD, Team AS, Insight 46 Study T, Australian Imaging B, Lifestyle S, Alzheimer’s Disease Neuroimaging I. KL *VS heterozygosity reduces brain amyloid in asymptomatic at-risk APOE *4 carriers. Neurobiol Aging. 2021;101:123-9. Epub 20210123. doi: 10.1016/j.neurobiolaging.2021.01.008. PubMed PMID: 33610961; PMCID: PMC8122023. 

Farrell ME, Jiang S, Schultz AP, Properzi MJ, Price JC, Becker JA, Jacobs HIL, Hanseeuw BJ, Rentz DM, Villemagne VL, Papp KV, Mormino EC, Betensky RA, Johnson KA, Sperling RA, Buckley RF, Alzheimer’s Disease Neuroimaging I, the Harvard Aging Brain S. Defining the Lowest Threshold for Amyloid-PET to Predict Future Cognitive Decline and Amyloid Accumulation. Neurology. 2021;96(4):e619-e31. Epub 20201116. doi: 10.1212/WNL.0000000000011214. PubMed PMID: 33199430; PMCID: PMC7905788. 

Grober E, Papp KV, Rentz DM, Sperling RA, Johnson KA, Amariglio RE, Schultz A, Lipton RB, Ezzati A. Neuroimaging correlates of Stages of Objective Memory Impairment (SOMI) system. Alzheimers Dement (Amst). 2021;13(1):e12224. Epub 20211231. doi: 10.1002/dad2.12224. PubMed PMID: 35005192; PMCID: PMC8719429. 

Jacobs HIL, Becker JA, Kwong K, Engels-Dominguez N, Prokopiou PC, Papp KV, Properzi M, Hampton OL, d’Oleire Uquillas F, Sanchez JS, Rentz DM, El Fakhri G, Normandin MD, Price JC, Bennett DA, Sperling RA, Johnson KA. In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer’s disease pathology and cognitive decline. Sci Transl Med. 2021;13(612):eabj2511. Epub 20210922. doi: 10.1126/scitranslmed.abj2511. PubMed PMID: 34550726; PMCID: PMC8641759. 

Jutten RJ, Rentz DM, Fu JF, Mayblyum DV, Amariglio RE, Buckley RF, Properzi MJ, Maruff P, Stark CE, Yassa MA, Johnson KA, Sperling RA, Papp KV. Monthly At-Home Computerized Cognitive Testing to Detect Diminished Practice Effects in Preclinical Alzheimer’s Disease. Front Aging Neurosci. 2021;13:800126. Epub 20220113. doi: 10.3389/fnagi.2021.800126. PubMed PMID: 35095476; PMCID: PMC8792465. 

Jutten RJ, Sikkes SAM, Amariglio RE, Buckley RF, Properzi MJ, Marshall GA, Rentz DM, Johnson KA, Teunissen CE, Van Berckel BNM, Van der Flier WM, Scheltens P, Sperling RA, Papp KV, Alzheimer Disease Neuroimaging I, National Alzheimer’s Coordinating Center tHABS, the Alzheimer Dementia C. Identifying Sensitive Measures of Cognitive Decline at Different Clinical Stages of Alzheimer’s Disease. J Int Neuropsychol Soc. 2021;27(5):426-38. Epub 20201013. doi: 10.1017/S1355617720000934. PubMed PMID: 33046162; PMCID: PMC8041916. 

Luo W, Wen H, Ge S, Tang C, Liu X, Lu L. Development of a Sex-Specific Risk Scoring System for the Prediction of Cognitively Normal People to Patients With Mild Cognitive Impairment (SRSS-CNMCI). Front Aging Neurosci. 2021;13:774804. Epub 20220125. doi: 10.3389/fnagi.2021.774804. PubMed PMID: 35145390; PMCID: PMC8823413. 

Mayblyum DV, Becker JA, Jacobs HIL, Buckley RF, Schultz AP, Sepulcre J, Sanchez JS, Rubinstein ZB, Katz SR, Moody KA, Vannini P, Papp KV, Rentz DM, Price JC, Sperling RA, Johnson KA, Hanseeuw BJ. Comparing PET and MRI Biomarkers Predicting Cognitive Decline in Preclinical Alzheimer Disease. Neurology. 2021;96(24):e2933-e43. Epub 20210614. doi: 10.1212/WNL.0000000000012108. PubMed PMID: 33952655; PMCID: PMC8253562. 

Munro CE, Buckley R, Vannini P, DeMuro C, Sperling R, Rentz DM, Johnson K, Gatchel JR, Amariglio R. Longitudinal Trajectories of Participant- and Study Partner-Rated Cognitive Decline, in Relation to Alzheimer’s Disease Biomarkers and Mood Symptoms. Front Aging Neurosci. 2021;13:806432. Epub 20220131. doi: 10.3389/fnagi.2021.806432. PubMed PMID: 35173601; PMCID: PMC8841868. 

Papp KV, Samaroo A, Chou HC, Buckley R, Schneider OR, Hsieh S, Soberanes D, Quiroz Y, Properzi M, Schultz A, Garcia-Magarino I, Marshall GA, Burke JG, Kumar R, Snyder N, Johnson K, Rentz DM, Sperling RA, Amariglio RE. Unsupervised mobile cognitive testing for use in preclinical Alzheimer’s disease. Alzheimers Dement (Amst). 2021;13(1):e12243. Epub 20210930. doi: 10.1002/dad2.12243. PubMed PMID: 34621977; PMCID: PMC8481881. 

Rentz DM, Papp KV, Mayblyum DV, Sanchez JS, Klein H, Souillard-Mandar W, Sperling RA, Johnson KA. Association of Digital Clock Drawing With PET Amyloid and Tau Pathology in Normal Older Adults. Neurology. 2021;96(14):e1844-e54. Epub 20210215. doi: 10.1212/WNL.0000000000011697. PubMed PMID: 33589537; PMCID: PMC8105970. 

Rodriguez-Vieitez E, Montal V, Sepulcre J, Lois C, Hanseeuw B, Vilaplana E, Schultz AP, Properzi MJ, Scott MR, Amariglio R, Papp KV, Marshall GA, Fortea J, Johnson KA, Sperling RA, Vannini P. Association of cortical microstructure with amyloid-beta and tau: impact on cognitive decline, neurodegeneration, and clinical progression in older adults. Mol Psychiatry. 2021;26(12):7813-22. Epub 20210929. doi: 10.1038/s41380-021-01290-z. PubMed PMID: 34588623; PMCID: PMC8873001.

Sanchez JS, Becker JA, Jacobs HIL, Hanseeuw BJ, Jiang S, Schultz AP, Properzi MJ, Katz SR, Beiser A, Satizabal CL, O’Donnell A, DeCarli C, Killiany R, El Fakhri G, Normandin MD, Gomez-Isla T, Quiroz YT, Rentz DM, Sperling RA, Seshadri S, Augustinack J, Price JC, Johnson KA. The cortical origin and initial spread of medial temporal tauopathy in Alzheimer’s disease assessed with positron emission tomography. Sci Transl Med. 2021;13(577). doi: 10.1126/scitranslmed.abc0655. PubMed PMID: 33472953; PMCID: PMC7978042. 

Vannini P, Gagliardi GP, Kuppe M, Dossett ML, Donovan NJ, Gatchel JR, Quiroz YT, Premnath PY, Amariglio R, Sperling RA, Marshall GA. Stress, resilience, and coping strategies in a sample of community-dwelling older adults during COVID-19. J Psychiatr Res. 2021;138:176-85. Epub 20210402. doi: 10.1016/j.jpsychires.2021.03.050. PubMed PMID: 33862301; PMCID: PMC8369528. 

2020

Aisen PS, Cummings J, Doody R, Kramer L, Salloway S, Selkoe DJ, Sims J, Sperling RA, Vellas B. The Future of Anti-Amyloid Trials. J Prev Alzheimers Dis. 2020;7(3):146-151. doi: 10.14283/jpad.2020.24. PMID: 32463066.

Amariglio RE, Buckley RF, Rabin JS, Papp KV, Quiroz YT, Mormino EC, Sparks KP, Johnson KA, Rentz DM, Sperling RA. Examining Cognitive Decline Across Black and White Participants in the Harvard Aging Brain Study. J Alzheimers Dis. 2020;75(4):1437-46. doi: 10.3233/JAD-191291. PubMed PMID: 32417775; PMCID: PMC7397774. 

Biddle KD, Jacobs HIL, d’Oleire Uquillas F, Zide BS, Kirn DR, Properzi MR, Rentz DM, Johnson KA, Sperling RA, Donovan NJ. Associations of Widowhood and β-Amyloid With Cognitive Decline in Cognitively Unimpaired Older Adults. JAMA Netw Open. 2020 Feb 5;3(2):e200121. doi: 10.1001/jamanetworkopen.2020.0121. PMID: 32101313; PMCID: PMC7099624.

Buckley RF, Scott MR, Jacobs HIL, Schultz AP, Properzi MJ, Amariglio RE, Hohman TJ, Mayblyum DV, Rubinstein ZB, Manning L, Hanseeuw BJ, Mormino EC, Rentz DM, Johnson KA, Sperling RA. Sex Mediates Relationships Between Regional Tau Pathology and Cognitive Decline. Ann Neurol. 2020;88(5):921-32. Epub 20200831. doi: 10.1002/ana.25878. PubMed PMID: 32799367; PMCID: PMC7581543. 

Chhatwal JP, Schultz AP, Dang Y, Ostaszewski B, Liu L, Yang HS, Johnson KA, Sperling RA, Selkoe DJ. Plasma N-terminal tau fragment levels predict future cognitive decline and neurodegeneration in healthy elderly individuals. Nat Commun. 2020;11(1):6024. Epub 20201127. doi: 10.1038/s41467-020-19543-w. PubMed PMID: 33247134; PMCID: PMC7695712. 

d’Oleire Uquillas F, Jacobs HIL, Schultz AP, Hanseeuw BJ, Buckley RF, Sepulcre J, Pascual-Leone A, Donovan NJ, Johnson KA, Sperling RA, Vannini P. Functional and Pathological Correlates of Judgments of Learning in Cognitively Unimpaired Older Adults. Cereb Cortex. 2020 Mar 14;30(3):1974-1983. doi: 10.1093/cercor/bhz217. PMID: 31696223; PMCID: PMC7132950.

Dubbelman MA, Jutten RJ, Tomaszewski Farias SE, Amariglio RE, Buckley RF, Visser PJ, Rentz DM, Johnson KA, Properzi MJ, Schultz A, Donovan N, Gatchell JR, Teunissen CE, Van Berckel BNM, Van der Flier WM, Sperling RA, Papp KV, Scheltens P, Marshall GA, Sikkes SAM, Alzheimer Disease Neuroimaging Initiative NAsCCtHABStADC. Decline in cognitively complex everyday activities accelerates along the Alzheimer’s disease continuum. Alzheimers Res Ther. 2020;12(1):138. Epub 20201029. doi: 10.1186/s13195-020-00706-2. PubMed PMID: 33121534; PMCID: PMC7597034. 

Gatchel JR, Lopera F, Norton DJ, Baena A, Guzman-Velez E, Sanchez JS, d’Oleire Uquillas F, Schultz A, Vannini P, Artola A, Amariglio RE, Rentz DM, Tariot PN, Reiman EM, Johnson KA, Sperling RA, Marshall GA, Quiroz YT. Association of subjective cognitive decline with markers of brain pathology in preclinical autosomal dominant Alzheimer’s disease. J Neurol Neurosurg Psychiatry. 2020 Mar;91(3):330-332. doi: 10.1136/jnnp-2019-321205. Epub 2019 Dec 24. PMID: 31874859.

Hampton OL, Buckley RF, Manning LK, Scott MR, Properzi MJ, Pena-Gomez C, Jacobs HIL, Chhatwal JP, Johnson KA, Sperling RA, Schultz AP. Resting-state functional connectivity and amyloid burden influence longitudinal cortical thinning in the default mode network in preclinical Alzheimer’s disease. Neuroimage Clin. 2020;28:102407. Epub 20200902. doi: 10.1016/j.nicl.2020.102407. PubMed PMID: 32942175; PMCID: PMC7498941. 

Hanseeuw BJ, Jonas V, Jackson J, Betensky RA, Rentz DM, Johnson KA, Sperling RA, Donovan NJ. Correction: Association of anxiety with subcortical amyloidosis in cognitively normal older adults. Mol Psychiatry. 2020;25(10):2644. doi: 10.1038/s41380-018-0323-y. PubMed PMID: 30538309; PMCID: PMC7609262. 

Jacobs HIL, Augustinack JC, Schultz AP, Hanseeuw BJ, Locascio J, Amariglio RE, Papp KV, Rentz DM, Sperling RA, Johnson KA. The presubiculum links incipient amyloid and tau pathology to memory function in older persons. Neurology. 2020 May 5;94(18):e1916-e1928. doi: 10.1212/WNL.0000000000009362. Epub 2020 Apr 9. PMID: 32273431; PMCID: PMC7274925.

McDonough IM, Popp TE. Linear and nonlinear relationships between cognitive subdomains of ability discrepancy and Alzheimer’s disease biomarkers. Neuropsychology. 2020;34(2):211-26. Epub 20191202. doi: 10.1037/neu0000606. PubMed PMID: 31789566; PMCID: PMC6987005. 

Papp KV, Buckley R, Mormino E, Maruff P, Villemagne VL, Masters CL, Johnson KA, Rentz DM, Sperling RA, Amariglio RE; Collaborators from the Harvard Aging Brain Study, the Alzheimer’s Disease Neuroimaging Initiative and the Australian Imaging, Biomarker and Lifestyle Study of Aging. Clinical meaningfulness of subtle cognitive decline on longitudinal testing in preclinical AD. Alzheimers Dement. 2020 Mar;16(3):552-560. doi: 10.1016/j.jalz.2019.09.074. Epub 2020 Jan 4. PMID: 31759879; PMCID: PMC7067681.

Putcha D, Dickerson BC, Brickhouse M, Johnson KA, Sperling RA, Papp KV. Word retrieval across the biomarker-confirmed Alzheimer’s disease syndromic spectrum. Neuropsychologia. 2020;140:107391. Epub 20200210. doi: 10.1016/j.neuropsychologia.2020.107391. PubMed PMID: 32057937; PMCID: PMC7085933. 

Rabin JS, Shirzadi Z, Swardfager W, MacIntosh BJ, Schultz A, Yang HS, Buckley RF, Gatchel JR, Kirn D, Pruzin JJ, Hedden T, Lipsman N, Rentz DM, Black SE, Johnson KA, Sperling RA, Chhatwal JP, Harvard Aging Brain S, Alzheimer’s Disease Neuroimaging I. Amyloid-beta burden predicts prospective decline in body mass index in clinically normal adults. Neurobiol Aging. 2020;93:124-30. Epub 20200307. doi: 10.1016/j.neurobiolaging.2020.03.002. PubMed PMID: 32249013; PMCID: PMC7429980. 

Rabin JS, Neal TE, Nierle HE, Sikkes SAM, Buckley RF, Amariglio RE, Papp KV, Rentz DM, Schultz AP, Johnson KA, Sperling RA, Hedden T. Multiple markers contribute to risk of progression from normal to mild cognitive impairment. Neuroimage Clin. 2020;28:102400. Epub 20200828. doi: 10.1016/j.nicl.2020.102400. PubMed PMID: 32919366; PMCID: PMC7491146. 

Samaroo A, Amariglio RE, Burnham S, Sparks P, Properzi M, Schultz AP, Buckley R, Johnson KA, Sperling RA, Rentz DM, Papp KV. Diminished Learning Over Repeated Exposures (LORE) in preclinical Alzheimer’s disease. Alzheimers Dement (Amst). 2020;12(1):e12132. Epub 20210105. doi: 10.1002/dad2.12132. PubMed PMID: 33426266; PMCID: PMC7784542. 

Sarkis RA, Beers L, Farah E, Al-Akaidi M, Zhang Y, Locascio JJ, Properzi MJ, Schultz AP, Chhatwal JP, Johnson KA, Sperling RA, P BP, Marshall GA. The neurophysiology and seizure outcomes of late onset unexplained epilepsy. Clin Neurophysiol. 2020;131(11):2667-72. Epub 20200919. doi: 10.1016/j.clinph.2020.08.014. PubMed PMID: 32957039; PMCID: PMC7644268. 

Schultz AP, Buckley RF, Hampton OL, Scott MR, Properzi MJ, Peña-Gómez C, Pruzin JJ, Yang HS, Johnson KA, Sperling RA, Chhatwal JP. Longitudinal degradation of the default/salience network axis in symptomatic individuals with elevated amyloid burden. Neuroimage Clin. 2020;26:102052. doi: 10.1016/j.nicl.2019.102052. Epub 2019 Oct 22. PMID: 31711955; PMCID: PMC7229343.

Scott MR, Hampton OL, Buckley RF, Chhatwal JP, Hanseeuw BJ, Jacobs HI, Properzi MJ, Sanchez JS, Johnson KA, Sperling RA, Schultz AP. Inferior temporal tau is associated with accelerated prospective cortical thinning in clinically normal older adults. Neuroimage. 2020;220:116991. Epub 20200605. doi: 10.1016/j.neuroimage.2020.116991. PubMed PMID: 32512123; PMCID: PMC7572623. 

Sperling RA, Donohue MC, Raman R, Sun CK, Yaari R, Holdridge K, Siemers E, Johnson KA, Aisen PS; A4 Study Team. Association of Factors With Elevated Amyloid Burden in Clinically Normal Older Individuals. JAMA Neurol. 2020 Apr 6;77(6):1–11. doi: 10.1001/jamaneurol.2020.0387. Epub ahead of print. PMID: 32250387; PMCID: PMC7136861.

Yang HS, White CC, Klein HU, Yu L, Gaiteri C, Ma Y, Felsky D, Mostafavi S, Petyuk VA, Sperling RA, Ertekin-Taner N, Schneider JA, Bennett DA, De Jager PL. Genetics of Gene Expression in the Aging Human Brain Reveal TDP-43 Proteinopathy Pathophysiology. Neuron. 2020 Jun 8:S0896-6273(20)30356-1. doi: 10.1016/j.neuron.2020.05.010. Epub ahead of print. PMID: 32526197.

2019

Biddle KD, d’Oleire Uquillas F, Jacobs HIL, Zide B, Kirn DR, Rentz DM, Johnson KA, Sperling RA, Donovan NJ. Social Engagement and Amyloid-β-Related Cognitive Decline in Cognitively Normal Older Adults. American Journal of Geriatric Psychiatry. 2019;27(11):1247-56. Epub 20190510. doi: 10.1016/j.jagp.2019.05.005. PubMed PMID: 31248770; PMCID: PMC6778491. 

Buckley RF, Mormino EC, Chhatwal J, Schultz AP, Rabin JS, Rentz DM, Acar D, Properzi MJ, Dumurgier J, Jacobs H, Gomez-Isla T, Johnson KA, Sperling RA, Hanseeuw BJ; Associations between baseline amyloid, sex, and APOE on subsequent tau accumulation in cerebrospinal fluid. Alzheimer’s Disease Neuroimaging Initiative. Neurobiology of Aging. 2019 Mar 7;78:178-185. doi: 10.1016/j.neurobiolaging.2019.02.019. [Epub ahead of print] PMID: 30947113; PMC In Process.

Buckley RF, Mormino EC, Rabin JS, Hohman TJ, Landau S, Hanseeuw BJ, Jacobs HIL, Papp KV, Amariglio RE, Properzi MJ, Schultz AP, Kirn D, Scott MR, Hedden T, Farrell M, Price J, Chhatwal J, Rentz DM, Villemagne VL, Johnson KA, Sperling RA. Sex Differences in the Association of Global Amyloid and Regional Tau Deposition Measured by Positron Emission Tomography in Clinically Normal Older Adults. JAMA Neurol. 2019 Feb 4. doi: 10.1001/jamaneurol.2018.4693. [Epub ahead of print] PubMed PMID: 30715078; NIHMSID: NIHMS1029661. PMC In Process.

Chen Z, Mengel D, Keshavan A, Rissman RA, Billinton A, Perkinton M, Percival-Alwyn J, Schultz A, Properzi M, Johnson K, Selkoe DJ, Sperling RA, Patel P, Zetterberg H, Galasko D, Schott JM, Walsh DM. Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer’s disease. Alzheimer’s & Dementia. 2019 March;15(3);487-496. PubMed PMID: 30419228; PubMed Central PMCID: PMC6476313.

d’Oleire Uquillas F, Jacobs HIL, Schultz AP, Hanseeuw BJ, Buckley RF, Sepulcre J, Pascual-Leone A, Donovan NJ, Johnson KA, Sperling RA, Vannini P. Functional and Pathological Correlates of Judgments of Learning in Cognitively Unimpaired Older Adults. Cereb Cortex. 2019 Nov 6;. doi: 10.1093/cercor/bhz217. [Epub ahead of print] PubMed PMID: 31696223.

Gatchel JR, Rabin JS, Buckley RF, Locascio JJ, Quiroz YT, Yang HS, Vannini P,  Amariglio RE, Rentz DM, Properzi M, Donovan NJ, Blacker D, Johnson KA, Sperling RA, Marshall GA; Harvard Aging Brain Study. Longitudinal Association of Depression Symptoms With Cognition and Cortical Amyloid Among Community-Dwelling Older Adults. JAMA Netw Open. 2019 Aug 2;2(8):e198964. doi: 10.1001/jamanetworkopen.2019.8964. PubMed PMID: 31397865.

Hanseeuw BJ, Scott MR, Sikkes SAM, Properzi M, Gatchel JR, Salmon E, Marshall GA, Vannini P. Evolution of anosognosia in alzheimer’s disease and its relationship to amyloid. Ann Neurol. 2019 Nov 21;. doi: 10.1002/ana.25649. [Epub ahead of print] PubMed PMID: 31750553; NIHMSID:NIHMS1066473.

Hanseeuw BJ, Betensky RA, Jacobs HIL, Schultz AP, Sepulcre J, Becker JA, Cosio DMO, Farrell M, Quiroz YT, Mormino EC, Buckley RF, Papp KV, Amariglio RA, Dewachter I, Ivanoiu A, Huijbers W, Hedden T, Marshall GA, Chhatwal JP, Rentz DM, Sperling RA, Johnson K. Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease: A Longitudinal Study. JAMA Neurol. 2019 Jun 3. doi: 10.1001/jamaneurol.2019.1424. [Epub ahead of print] PubMed PMID: 31157827; PubMed Central PMCID: PMC6547132.

Hanseeuw BJ, Lopera F, Sperling RA, Norton DJ, Guzman-Velez E, Baena A, Pardilla-Delgado E, Schultz AP, Gatchel J, Jin D, Chen K, Reiman EM, Johnson KA, Quiroz YT. Striatal amyloid is associated with tauopathy and memory decline in familial Alzheimer’s disease. Alzheimers Research Therapy. 2019 Feb 4;11(1):17. doi:10.1186/s13195-019-0468-1. PubMed PMID: 30717814; PubMed Central PMCID: PMC6362587.

Huijbers W, Schultz AP, Papp KV, LaPoint MR, Hanseeuw B, Chhatwal JP, Hedden T, Johnson KA, Sperling RA. Tau Accumulation in Clinically Normal Older Adults Is Associated with Hippocampal Hyperactivity. The Journal of Neuroscience. 2019 January 16;39(3):548-556. PubMed PMID: 30482786; PubMed Central PMCID: PMC6335746.

Lois C, Gonzalez I, Johnson KA, Price JC. PET imaging of tau protein targets: a methodology perspective. Brain Imaging and Behavior. 2019 April;13(2):333-344. PubMed PMID: 29497982; PubMed Central PMCID: PMC6119534.

Marshall GA, Aghjayan SL, Dekhtyar M, Locascio JJ, Jethwani K, Amariglio RE, Czaja SJ, Loewenstein DA, Johnson KA, Sperling RA, Rentz DM. Measuring instrumental activities of daily living in non-demented elderly: a comparison of the new performance-based Harvard Automated Phone Task with other functional assessments. Alzheimers Research Therapy. 2019 Jan 10;11(1):4. doi: 10.1186/s13195-018-0464-x. PMID: 30630529; PubMed Central PMCID: PMC6329044.

Marshall GA, Gatchel JR, Donovan NJ, Muniz MC, Schultz AP, Becker JA, Chhatwal JP, Hanseeuw BJ, Papp KV, Amariglio RE, Rentz DM, Sperling RA, Johnson KA. Regional Tau Correlates of Instrumental Activities of Daily Living and Apathy in Mild Cognitive Impairment and Alzheimer’s Disease Dementia. J Alzheimers Disease. 2019;67(2):757-768. doi: 10.3233/JAD-170578. PubMed PMID: 30689584; PubMed Central PMCID: PMC6352915.

Properzi MJ, Buckley RF, Chhatwal JP, Donohue MC, Lois C, Mormino EC, Johnson KA, Sperling RA, Schultz AP. Nonlinear Distributional Mapping (NoDiM) for harmonization across amyloid-PET radiotracers. NeuroImage. 2019 February 1;1 86:446-454. PubMed PMID: 30458305; PubMed Central PMCID: PMC6338495.

Rabin JS, Klein H, Kirn DR, Schultz AP, Yang HS, Hampton O, Jiang S, Buckley RF, Viswanathan A, Hedden T, Pruzin J, Yau WW, Guzman-Velez E, Quiroz YT, Properzi M, Marshall GA, Rentz DM, Johnson KA, Sperling RA, Chhatwal JP. Associations of Physical Activity and beta-Amyloid With Longitudinal Cognition and Neurodegeneration in Clinically Normal Older Adults. JAMA Neurol. 2019;76(10):1203-10. doi: 10.1001/jamaneurol.2019.1879. PubMed PMID: 31312836; PMCID: PMC6635892. 

Rabin JS, Klein H, Kirn D, Schultz A, Yang HS, Hampton O, Jiang S, Buckley R, Viswanathan  A, Hedden T, Pruzin J, Yau WY, Guzman-Velez E, Quiroz Y, Properzi M, Marshall GA, Rentz DM, Johnson KA, Sperling RA, Jasmeer P. Chhatwal. Physical activity moderates the association of β-amyloid burden on longitudinal cognition and neurodegeneration in clinically-normal older adults. Annals of Neurology (In press). PMC In Process.

Rabin JS, Perea RD, Buckley RF, Neal TE, Buckner RL, Johnson KA, Sperling RA, Hedden T.  Global White Matter Diffusion Characteristics Predict Longitudinal Cognitive Change Independently of Amyloid Status in Clinically Normal Older Adults. Cerebral Cortex (New York, N.Y. 1991). 2019 Mar 1;29(3):1251-1262. PubMed PMID: 29425267; PubMed Central PMCID: PMC6499008.

Rabin JS, Yang HS, Schultz AP, Hanseeuw BJ, Hedden T, Viswanathan A, Gatchel JR, Marshall GA, Kilpatrick E, Klein H, Rao V, Buckley RF, Yau WW, Kirn DR, Rentz DM, Johnson KA, Sperling RA, Chhatwal JP. Vascular Risk and β-Amyloid Are Synergistically Associated with Cortical Tau. Annals of Neurology 2019 February;85(2):272-279. PubMed PMID: 30565287; PubMed Central PMCID: PMC6351182.

Rabin, JS, Perea, R, Buckley, RF, Johnson, KA, Sperling, RA, Hedden, T. Synergism between fornix microstructure and beta-amyloid accelerates memory decline in clinically normal older adults. Neurobiology of Aging. (In press). PMC In Process.

Sperling RA, Mormino EC, Schultz AP, Betensky RA, Papp KV, Amariglio RE, Hanseeuw BJ,  Buckley R, Chhatwal J, Hedden T, Marshall GA, Quiroz YT, Donovan NJ, Jackson J, Gatchel JR, Rabin JS, Jacobs H, Yang HS, Properzi M, Kirn DR, Rentz DM, Johnson KA. The impact of amyloid-beta and tau on prospective cognitive decline in older individuals. Annals of Neurology. 2019 February;85(2):181-193. PubMed PMID:30549303; PubMed Central PMCID: PMC6402593.

Vannini P, Uquillas FD, Jacobs HIL, Sepulcre J, Gatchel J, Amariglio RE, Hanseeuw B, Papp KV, Hedden T, Rentz DM, Pascual-Leone A, Johnson KA, Sperling RA. Decreased meta-memory is associated with early tauopathy in cognitively unimpaired older adults. Neuroimage Clin. 2019;24:102097. doi: 10.1016/j.nicl.2019.102097. Epub 2019 Nov 18. PubMed PMID: 31795044; PubMed Central PMCID: PMC6879982.

Yang HS, Chhatwal JP, Xu J, White CC, Hanseeuw B, Rabin JS, Papp KV, Buckley RF, Schultz AP, Properzi MJ, Gatchel JR, Amariglio RE, Donovan NJ, Mormino EC, Hedden T, Marshall GA, Rentz DM, Johnson KA, De Jager PL, Sperling RA. An UNC5C Allele Predicts Cognitive Decline and Hippocampal Atrophy in Clinically Normal Older Adults. J Alzheimers Dis. 2019;68(3):1161-70. doi: 10.3233/JAD-180788. PubMed PMID: 30883345; PMCID: PMC6571137. 

2018

Amariglio RE, Buckley RF, Mormino EC, Marshall GA, Johnson KA, Rentz DM, Sperling RA. Amyloid-associated increases in longitudinal report of subjective cognitive complaints. Alzheimer’s Dementia (New York, N. Y.). 2018 September 6;4:444-449. PubMed PMID: 30258973; PubMed Central PMCID: PMC6153378.

Buckley RF, Mormino EC, Amariglio RE, Properzi MJ, Rabin JS, Lim YY, Papp KV, Jacobs HIL, Burnham S, Hanseeuw BJ, Doré V, Dobson A, Masters CL, Waller M, Rowe CC, Maruff P, Donohue MC, Rentz DM, Kirn D, Hedden T, Chhatwal J, Schultz AP, Johnson KA, Villemagne VL, Sperling RA. Sex, amyloid, and APOE ε4 and risk of cognitive decline in preclinical Alzheimer’s disease: Findings from three well- characterized cohorts. Alzheimer’s Dementia. 2018 September;14(9):1193-1203. PubMed PMID: 29803541; PubMed Central PMCID: PMC6131023.

Chhatwal JP, Schultz AP, Johnson KA, Hedden T, Jaimes S, Benzinger TLS, Jack C Jr, Ances BM, Ringman JM, Marcus DS, Ghetti B, Farlow MR, Danek A, Levin J, Yakushev I, Laske C, Koeppe RA, Galasko DR, Xiong C, Masters CL, Schofield PR, Kinnunen KM, Salloway S, Martins RN, McDade E, Cairns NJ, Buckles VD, Morris JC, Bateman R, Sperling RA. Preferential degradation of cognitive networks differentiates Alzheimer’s disease from ageing. Brain a Journal of Neurology. 2018 May 1;141(5):1486-1500. PubMed PMID: 29522171; PubMed Central PMCID: PMC5917745.

Chiou SH, Austin MD, Qian J, Betensky RA. Transformation model estimation of survival under dependent truncation and independent censoring. Statistical Methods in Medical Research. 2018 December 13:1-14;962280218817573. PubMed PMID: 30543153; NIHMSID: NIHMS1029640. PMC In Process.

Chiou SH, Qian J, Mormino E, Betensky RA; Alzheimer’s Disease Neuroimaging Initiative; Australian Imaging Biomarkers Lifestyle Flagship Study of Aging; Harvard Aging Brain Study. Permutation Tests for General Dependent Truncation. Comput Stat Data Anal. 2018 Dec; 128:308-324. doi: 10.1016/j.csda.2018.07.012. Epub 2018 Jul 29. PubMed PMID: 30613119; PubMed Central PMCID: PMC6317381.

d’Oleire Uquillas F, Jacobs HIL, Biddle KD, Properzi M, Hanseeuw B, Schultz AP, Rentz DM, Johnson KA, Sperling RA, Donovan NJ. Regional tau pathology and loneliness in cognitively normal older adults. Translational Psychiatry. 2018 December 18;8(1):282. PubMed PMID: 30563962; PubMed Central PMCID: PMC6299114.

d’Oleire Uquillas F, Jacobs HIL, Hanseeuw B, Marshall GA, Properzi M, Schultz AP, LaPoint MR, Johnson KA, Sperling RA, Vannini P. Interactive versus additive relationships between regional cortical thinning and amyloid burden in predicting clinical decline in mild AD and MCI individuals. Neuroimage Clin. 2018;17:388-396. doi: 10.1016/j.nicl.2017.10.034. eCollection 2018. PubMed PMID: 29159051; PubMed Central PMCID: PMC5683806.

Donovan NJ, Locascio JJ, Marshall GA, Gatchel J, Hanseeuw BJ, Rentz DM, Johnson KA, Sperling RA. Longitudinal Association of Amyloid Beta and Anxious-Depressive Symptoms in Cognitively Normal Older Adults. The American Journal of Psychiatry. 2018 June 1;175(6):530-537. PubMed PMID: 29325447; PubMed Central PMCID: PMC5988933.

Hanseeuw BJ, Betensky RA, Mormino EC, Schultz AP, Sepulcre J, Becker JA, Jacobs HIL, Buckley RF, LaPoint MR, Vannini P, Donovan NJ, Chhatwal JP, Marshall GA, Papp KV, Amariglio RE, Rentz DM, Sperling RA, Johnson KA. PET staging of amyloidosis using striatum. Alzheimer’s & Dementia. 2018 October;14(10):1281-1292. PubMed PMID: 29792874; PubMed Central PMCID: PMC6219621.

Hanseeuw BJ, Jonas V, Jackson J, Betensky RA, Rentz DM, Johnson KA, Sperling RA, Donovan NJ. Association of anxiety with subcortical amyloidosis in cognitively normal older adults. Molecular Psychiatry. 2018 August 16;1-9. PubMed PMID: 30116029; PubMed Central PMCID: PMC6377864.

Jacobs HIL, Hedden T, Schultz AP, Sepulcre J, Perea RD, Amariglio RE, Papp KV, Rentz DM, Sperling RA, Johnson KA. Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals. Nature Neuroscience. 2018 March;21(3):424-431. PubMed PMID: 29403032; PubMed Central PMCID: PMC5857215.

Lee C, Betensky RA. Time-to-event data with time-varying biomarkers measured only at study entry, with applications to Alzheimer’s disease. Statistics in Medicine. 2018 Mar 15;37(6):914-932. PubMed PMID: 29266591; PubMed Central PMCID: PMC5801265.

Lee CM, Jacobs HIL, Marquié M, Becker JA, Andrea NV, Jin DS, Schultz AP, Frosch MP, Gómez-Isla T, Sperling RA, Johnson KA. 18F-Flortaucipir Binding in Choroid Plexus: Related to Race and Hippocampus Signal. Journal of Alzheimer’s Disease. 2018;62(4):1691-1702. PubMed PMID: 29614677; PubMed Central PMCID: PMC5957532.

Munro CE, Donovan NJ, Amariglio RE, Papp KV, Marshall GA, Rentz DM, Pascual-Leone A, Sperling RA, Locascio JJ, Vannini P. The Impact of Awareness of and Concern About Memory Performance on the Prediction of Progression From Mild Cognitive Impairment to Alzheimer Disease Dementia. Am J Geriatr Psychiatry. 2018 Aug;26(8):896-904. doi: 10.1016/j.jagp.2018.04.008. Epub 2018 May 3. PubMed PMID: 29866588; PubMed Central PMCID: PMC6959130.

Orlovsky I, Huijbers W, Hanseeuw BJ, Mormino EC, Hedden T, Buckley RF, LaPoint M, Rabin JS, Rentz DM, Johnson KA, Sperling RA, Papp KV. The relationship between recall of recently versus remotely encoded famous faces and amyloidosis in clinically normal older adults. Alzheimer’s & Dementia (Amsterdam, Netherlands).2018;10:121-129. PubMed PMID: 29780861; PubMed Central PMCID: PMC5956796.

Perea RD, Rabin JS, Fujiyoshi MG, Neal TE, Smith EE, Van Dijk KRA, Hedden T. Connectome-derived diffusion characteristics of the fornix in Alzheimer’s disease. NeuroImage. Clinical. 2018 April 27; 19:331-342. PubMed PMID: 30013916; PubMed Central PMCID: PMC6044183.

Qian J, Chiou SH, Maye JE, Atem F, Johnson KA, Betensky RA. Threshold regression to accommodate a censored covariate. Biometrics. 2018 Dec;74(4):1261-1270. PubMed PMID: 29933515; PubMed Central PMCID: PMC6321791.

Quiroz YT, Sperling RA, Norton DJ, Baena A, Arboleda-Velasquez JF, Cosio D, Schultz A, Lapoint M, Guzman-Velez E, Miller JB, Kim LA, Chen K, Tariot PN, Lopera F, Reiman EM, Johnson KA. Association Between Amyloid and Tau Accumulation in Young Adults With Autosomal Dominant Alzheimer Disease. JAMA Neurology. 2018 May 1;75(5):548-556. PubMed PMID: 29435558; PubMed Central PMCID: PMC5885174.

Rabin JS, Schultz AP, Hedden T, Viswanathan A, Marshall GA, Kilpatrick E, Klein H, Buckley RF, Yang HS, Properzi M, Rao V, Kirn DR, Papp KV, Rentz DM, Johnson KA, Sperling RA, Chhatwal JP. Interactive Associations of Vascular Risk and β-Amyloid Burden with Cognitive Decline in Clinically Normal Elderly Individuals: Findings from the Harvard Aging Brain Study. JAMA Neurology. 2018 September 1;75(9):1124-1131. PubMed PMID: 29799986; PubMed Central PMCID: PMC6143121.

Rieckmann A, Johnson KA, Sperling RA, Buckner RL, Hedden T. Dedifferentiation of   caudate functional connectivity and striatal dopamine transporter density predict memory change in normal aging. Proceedings of the National Academy of Sciences of the United States of America. 2018 October 2;115(40):10160-10165. PubMed PMID: 30224467; PubMed Central PMCID: PMC6176586.

Sepulcre J, Grothe MJ, d’Oleire Uquillas F, Ortiz-Terán L, Diez I, Yang HS, Jacobs HIL, Hanseeuw BJ, Li Q, El-Fakhri G, Sperling RA, Johnson KA. Neurogenetic contributions to amyloid beta and tau spreading in the human cortex. Nature Medicine. 2018 December;24(12):1910-1918. PubMed PMID: 30374196; NIHMSID: NIHMS1027665. PMC In Process.

Zott B, Busche MA, Sperling RA, Konnerth A. What Happens with the Circuit in Alzheimer’s Disease in Mice and Humans? Annual Review Neuroscience. 2018 Jul 8;41:277-297. 10.1146/annurev-neuro-080317-061725 PMID: 29986165. NIHMSID: NIHMS1029649. PMC In Process.

2017

Aghjayan SL, Buckley RF, Vannini P, Rentz DM, Jackson JD, Sperling RA, Johnson KA, Amariglio RE. The influence of demographic factors on subjective cognitive concerns and beta-amyloid. International Psychogeriatrics. 2017 Apr;29(4):645-652. PubMed PMID: 27724996; PubMed Central PMCID: PMC5361739.

Atem FD, Qian, J, Maye JE, Johnson KA, Betensky RA, Linear Regression with a Randomly Censored Covariate: Application to an Alzheimer’s Study. Journal of the Royal Statistical Society. SeriesC, Applied statistics. 2017;66(2):313-328. doi:10.1111/rssc.12164. Epub 2016 Jun 27. PMID: 28239197; PubMed Central PMCID: PMC5319605.

Buckley RF, Hanseeuw B, Schultz AP, Vannini P, Aghjayan SL, Properzi MJ, Jackson JD, Mormino EC, Rentz DM, Sperling RA, Johnson KA, Amariglio RE. Region-Specific Association of Subjective Cognitive Decline with Tauopathy Independent of Global β- Amyloid Burden. JAMA Neurology. 2017 December 1;74(12):1455-1463. PubMed PMID: 28973551; PubMed Central PMCID: PMC5774633.

Buckley RF, Schultz AP, Hedden T, Papp KV, Hanseeuw BJ, Marshall G, Sepulcre J, Smith EE, Rentz DM, Johnson KA, Sperling RA, Chhatwal JP. Functional network integrity presages cognitive decline in preclinical Alzheimer disease. Neurology. 2017 July 4;89(1):29-37. PubMed PMID: 28592457; PubMed Central PMCID: PMC5496516.

Buckley RF, Sparks KP, Papp KV, Dekhtyar M, Martin C, Burnham S, Sperling RA, Rentz DM. Computerized Cognitive Testing for Use in Clinical Trials: A Comparison of the NIH Toolbox and Cogstate C3 Batteries. The Journal of Prevention of Alzheimer Disease. 2017;4(1):3-11. PubMed PMID: 29188853; PubMed Central PMCID: PMC5726304.

Dagley A, LaPoint M, Huijbers W, Hedden T, McLaren DG, Chatwal JP, Papp KV, Amariglio RE, Blacker D, Rentz DM, Johnson KA, Sperling RA, Schultz AP. Harvard Aging Brain Study: Dataset and accessibility. Neuroimage. 2017 Jan;144(Pt B):255-258; PubMed PMID: 25843019; PubMed Central PMCID: PMC4592689.

Dekhtyar M, Papp KV, Buckley R, Jacobs HIL, Schultz AP, Johnson KA, Sperling RA, Rentz DM. Neuroimaging markers associated with maintenance of optimal memory performance in late-life. Neuropsychologia. 2017 June;100:164-170. PubMed PMID: 28472627; PubMed Central PMCID: PMC5522601.

Donovan NJ, Wu Q, Rentz DM, Sperling RA, Marshall GA, Glymour MM. Loneliness, depression and cognitive function in older U.S. adults. International Journal of Geriatric Psychiatry. 2017 May;32(5):564-573. PubMed PMID: 27162047; PubMed Central PMCID: PMC5102822.

Dumurgier J, Hanseeuw BJ, Hatling FB, Judge KA, Schultz AP, Chhatwal JP, Blacker D, Sperling RA, Johnson KA, Hyman BT, Gómez-Isla T. Alzheimer’s Disease Biomarkers and Future Decline in Cognitive Normal Older Adults. Journal of Alzheimer’s Disease: JAD. 2017;60(4):1451-1459. PubMed PMID: 29036824; PubMed Central PMCID: PMC5773095.

Gatchel JR, Donovan NJ, Locascio JJ, Schultz AP, Becker JA, Chhatwal J, Papp KV, Amariglio RE, Rentz DM, Blacker D, Sperling RA, Johnson KA, Marshall GA. Depressive Symptoms and Tau Accumulation in the Inferior Temporal Lobe and Entorhinal Cortex in Cognitively Normal Older Adults: A Pilot Study. Journal of Alzheimer’s Disease: JAD. 2017;59(3):975-985. PubMed PMID: 28697559; PubMed Central PMCID: PMC5577564.

Hanseeuw BJ, Betensky RA, Schultz AP, Papp KV, Mormino EC, Sepulcre J, Bark JS, Cosio DM, LaPoint M, Chhatwal JP, Rentz DM, Sperling RA, Johnson KA. Fluorodeoxyglucose metabolism associated with tau-amyloid interaction predicts memory decline. Annals of Neurology. 2017 April;81(4):583-596. PubMed PMID: 28253546; PubMed Central PMCID: PMC5404378.

Huijbers W, Papp KV, LaPoint M, Wigman SE, Dagley A, Hedden T, Rentz DM, Schultz AP, Sperling RA. Age-Related Increases in Tip-of-the-tongue are Distinct from Decreases in Remembering Names: A Functional MRI Study. Cerebral Cortex (New York, N.Y.1991). 2017 Sep 1;27(9):4339-4349. PubMed PMID: 27578492; PubMed Central PMCID: PMC6074848.

LaPoint MR, Chhatwal JP, Sepulcre J, Johnson KA, Sperling RA, Schultz AP. The association between tau PET and retrospective cortical thinning in clinically normal elderly. NeuroImage. 2017 August 15;157:612-622. PubMed PMID: 28545932; PubMed Central PMCID: PMC5772972.

Marquié M, Normandin MD, Meltzer AC, Siao Tick Chong M, Andrea NV, Antón- Fernández A, Klunk WE, Mathis CA, Ikonomovic MD, Debnath M, Bien EA, Vanderburg CR, Costantino I, Makaretz S, DeVos SL, Oakley DH, Gomperts SN, Growdon JH, Domoto-Reilly K, Lucente D, Dickerson BC, Frosch MP, Hyman BT, Johnson KA, Gómez-Isla T. Pathological correlations of [F-18]-AV-1451 imaging in non-alzheimer tauopathies. Annals of Neurology. 2017 January;81(1):117-128. PubMed PMID: 27997036; PubMed Central PMCID: PMC5319193.

Marquié M, Siao Tick Chong M, Antón-Fernández A, Verwer EE, Sáez-Calveras N, Meltzer AC, Ramanan P, Amaral AC, Gonzalez J, Normandin MD, Frosch MP, Gómez- Isla T. [F-18]-AV-1451 binding correlates with postmortem neurofibrillary tangle Braak staging. Acta Neuropathologica. 2017 October;134(4):619-628. PubMed PMID: 28612291; PubMed Central PMCID: PMC5772971.

Marshall GA, Aghjayan SL, Dekhtyar M, Locascio JJ, Jethwani K, Amariglio RE, Johnson KA, Sperling RA, Rentz DM. Activities of daily living measured by the Harvard Automated Phone Task track with cognitive decline over time in non-demented elderly. The Journal of Prevention of Alzheimer’s Disease. 2017;4(2):81-86. PubMed PMID: 29124043; PubMed Central PMCID: PMC5675571.

McDonough IM, Beta-amyloid and Cortical Thickness Reveal Racial Disparities in Preclinical Alzheimer’s Disease. NeuroImage Clinical 2017 Sep 21;16:659-667. doi: 10.1016/j.nicl.2017.09.014. PubMed PMID: 29868439; PubMed Central PMCID: PMC5984571.

Molinuevo JL, Rabin LA, Amariglio R, Buckley R, Dubois B, Ellis KA, Ewers M, Hampel H, Klöppel S, Rami L, Reisberg B, Saykin AJ, Sikkes S, Smart CM, Snitz BE, Sperling R, van der Flier WM, Wagner M, Jessen F. Implementation of subjective cognitive decline criteria in research studies. Alzheimer’s Dementia: The journal of the Alzheimer’s Association. 2017 March;13(3):296-311. PubMed PMID: 27825022; PubMed Central PMCID: PMC5344703.

Mormino EC, Papp KV, Rentz DM, Donohue MC, Amariglio R, Quiroz YT, Chhatwal J, Marshall GA, Donovan N, Jackson J, Gatchel JR, Hanseeuw BJ, Schultz AP, Aisen PS, Johnson KA, Sperling RA. Early and late change on the preclinical Alzheimer’s cognitive composite in clinically normal older individuals with elevated amyloid β. Alzheimers Dementia. Alzheimer’s Association. 2017 September;13(9):1004-1012. PubMed PMID: 28253478; PubMed Central PMCID: PMC5573651.

Papp KV, Rentz DM, Mormino EC, Schultz AP, Amariglio RE, Quiroz Y, Johnson KA, Sperling RA. Cued memory decline in biomarker-defined preclinical Alzheimer disease. Neurology. 2017 April 11;88(15):1431-1438. PubMed PMID: 28283594; PubMed Central PMCID: PMC5386436.

Papp KV, Rentz DM, Orlovsky I, Sperling RA, Mormino EC. Optimizing the preclinical Alzheimer’s cognitive composite with semantic processing: The PACC5. Alzheimer’s Dementia (New York, N. Y.). 2017 November;3(4):668-677. PubMed PMID: 29264389; PubMed Central PMCID: PMC5726754.

Prčkovska V, Huijbers W, Schultz A, Ortiz-Teran L, Peña-Gomez C, Villoslada P, Johnson K, Sperling R, Sepulcre J. Epicenters of dynamic connectivity in the adaptation of the ventral visual system. Human Brain Mapping. 2017 April;38(4):1965-1976. PubMed PMID: 28029725; PubMed Central PMCID: PMC5342908.

Qian J, Hyman BT, Betensky RA. Neurofibrillary Tangle Stage and the Rate of Progression of Alzheimer Symptoms: Modeling Using an Autopsy Cohort and Application to Clinical Trial Design. JAMA Neurology. 2017 May 1;74(5):540-548. PubMed PMID: 28288263; PubMed Central PMCID: PMC5547572.

Qian J, Wolters FJ, Beiser A, Haan M, Ikram MA, Karlawish J, Langbaum JB, Neuhaus JM, Reiman EM, Roberts JS, Seshadri S, Tariot PN, Woods BM, Betensky RA, Blacker D. APOE-related risk of mild cognitive impairment and dementia for prevention trials: An analysis of four cohorts. PLoS Medicine. 2017 March;14(3):e1002254. PubMed PMID: 28323826; PubMed Central PMCID: PMC5360223.

Rentz DM, Mormino EC, Papp KV, Betensky RA, Sperling RA, Johnson KA. Cognitive resilience in clinical and preclinical Alzheimer’s disease: The Association of Amyloid and Tau Burden on cognitive performance. Brain Imaging and Behavior. 2017 April;11(2):383-390. PubMed PMID: 27738998; PubMed Central PMCID: PMC5391311.

Schultz AP, Chhatwal JP, Hedden T, Mormino EC, Hanseeuw BJ, Sepulcre J, Huijbers W, LaPoint M, Buckley RF, Johnson KA, Sperling RA. Phases of Hyperconnectivity and Hypoconnectivity in the Default Mode and Salience Networks Track with Amyloid and Tau in Clinically Normal Individuals. The Journal of Neuroscience. 2017 April 19;37(16):4323-4331. PubMed PMID:28314821; PubMed Central PMCID: PMC5413178.

Sepulcre J, Grothe MJ, Sabuncu M, Chhatwal J, Schultz AP, Hanseeuw B, El Fakhri G, Sperling R, Johnson KA. Hierarchical Organization of Tau and Amyloid Deposits in the Cerebral Cortex. JAMA Neurology. 2017 July 1;74(7):813-820. PubMed PMID: 28558094; PubMed Central PMCID: PMC5710537.

Sepulcre J, Sabuncu MR, Li Q, El Fakhri G, Sperling R, Johnson KA. Tau and amyloid β proteins distinctively associate to functional network changes in the aging brain. Alzheimer’s Dementia. 2017 November;13(11):1261-1269. PubMed PMID: 28366797; PubMed Central PMCID: PMC5623176.

Vannini P, Amariglio R, Hanseeuw B, Johnson KA, McLaren DG, Chhatwal J, Pascual-Leone A, Rentz D, Sperling RA. Memory self-awareness in the preclinical and prodromal stages of Alzheimer’s disease. Neuropsychologia. 2017 May;99:343-349.PubMed PMID: 28385579; PubMed Central PMCID: PMC5473166.

Vannini P, Hanseeuw B, Munro CE, Amariglio RE, Marshall GA, Rentz DM, Pascual- Leone A, Johnson KA, Sperling RA. Anosognosia for memory deficits in mild cognitive impairment: Insight into the neural mechanism using functional and molecular imaging. NeuroImage Clinical. 2017; 15:408-414. PubMed PMID: 28616381; PubMed Central PMCID: PMC5458095.

Vannini P, Hanseeuw B, Munro CE, Amariglio RE, Marshall GA, Rentz DM, Pascual- Leone A, Johnson KA, Sperling RA. Hippocampal hypometabolism in older adults with memory complaints and increased amyloid burden. Neurology. 2017 May 2;88(18):1759-1767. PubMed PMID: 28381517; PubMed Central PMCID: PMC5409840.

Wooten D, Guehl NJ, Verwer EE, Shoup TM, Yokell DL, Zubcevik N, Vasdev N, Zafonte RD, Johnson KA, El Fakhri G, Normandin MD. Pharmacokinetic evaluation of the tau PET radiotracer [18F]T807 ([18F]AV-1451) in human subjects. Journal of Nuclear Medicine, Society of Nuclear Medicine. 2017 March;58(3):484-491. PubMed PMID: 27660144; PubMed Central PMCID: PMC5334185.

Xia C, Makaretz SJ, Caso C, McGinnis S, Gomperts SN, Sepulcre J, Gomez-Isla T, Hyman BT, Schultz A, Vasdev N, Johnson KA, Dickerson BC. Association of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease. JAMA Neurology. 2017 April 1;74(4):427-436. PubMed PMID: 28241163; PubMed Central PMCID: PMC5470368.

Zhang J, Zhou W, Wang L, Zhang X. Gender differences of neuropsychological profiles in cognitively normal older people without amyloid pathology. Comprehensive Psychiatry. 2017 May;75:22-26. PubMed PMID: 28285181; PubMed Central PMCID: PMC5783637.

2016

Atem FD, Qian J, Maye JE, Johnson KA, Betensky RA. Multiple Imputation of a Randomly Censored Covariate Improves Logistic Regression Analysis. Journal of Applied Statistics. 2016;43(15):2886-2896. PubMed PMID: 27713593; PubMed Central PMCID: PMC5047523.

Buckley RF, Villemagne VL, Masters CL, Ellis KA, Rowe CC, Johnson K, Sperling R, Amariglio R. A Conceptualization of the Utility of Subjective Cognitive Decline in Clinical Trials of Preclinical Alzheimer’s Disease. Journal of Molecular Neuroscience: MN. 2016 November;60(3):354-361. PubMed PMID: 27514526; PubMed Central PMCID: PMC5241130.

Chan G, White CC, Winn PA, Cimpean M, Replogle JM, Glick LR, Cuerdon NE, Ryan KJ, Johnson KA, Schneider JA, Bennett DA, Chibnik LB, Sperling RA, De Jager PL, Bradshaw EM. Trans-pQTL study identifies immune crosstalk between Parkinson and Alzheimer loci. Neurology Genetics. 2016 July 26;2(4):e90. PubMed PMID: 27504496; PubMed Central PMCID: PMC4962525.

Chhatwal JP, Schultz AP, Marshall GA, Boot B, Gomez-Isla T, Dumurgier J, LaPoint M, Scherzer C, Roe AD, Hyman BT, Sperling RA, Johnson KA. Temporal T807 binding correlates with CSF tau and phospho-tau in normal elderly. Neurology. 2016 August 30;87(9):920-6. PubMed PMID: 27473132; PubMed Central PMCID: PMC5035159.

Dhilla Albers A, Asafu-Adjei J, Delaney MK, Kelly KE, Gomez-Isla T, Blacker D, Johnson KA, Sperling RA, Hyman BT, Betensky RA, Hastings L, Albers MW. Episodic memory of odors stratifies Alzheimer biomarkers in normal elderly. Annals of Neurology. 2016 December;80(6):846-857. PubMed PMID: 27696605; PubMed Central PMCID: PMC5177522.

Donovan NJ, Okereke OI, Vannini P, Amariglio RE, Rentz DM, Marshall GA, Johnson KA, Sperling RA. Association of Higher Cortical Amyloid Burden with Loneliness in Cognitively Normal Older Adults. JAMA Psychiatry. 2016 December 1;73(12):1230-1237. PubMed PMID: 27806159; PubMed Central PMCID: PMC5257284.

Fotiadis P, van Rooden S, van der Grond J, Schultz A, Martinez-Ramirez S, Auriel E, Reijmer Y, van Opstal AM, Ayres A, Schwab KM, Alzheimer's Disease Neuroimaging Initiative Adni, Hedden T, Rosand J, Viswanathan A, Wermer M, Terwindt GM, Sperling RA, Polimeni JR, Johnson KA, van Buchem MA, Greenberg SM, Gurol ME. Cortical atrophy in patients with cerebral amyloid angiopathy: a case-control study. The Lancet. Neurology. 2016 July;15(8):811-9. PubMed PMID: 27180034; PubMed Central PMCID: PMC5248657.

Gomperts SN, Locascio JJ, Makaretz SJ, Schultz A, Caso C, Vasdev N, Sperling R, Growdon JH, Dickerson BC, Johnson K. Tau Positron Emission Tomographic Imaging in the Lewy Body Diseases. JAMA Neurology. 2016 November 1;73(11):1334-1341. PubMed PMID: 27654968; PubMed Central PMCID: PMC5287290.

Gomperts SN, Marquie M, Locascio JJ, Bayer S, Johnson KA, Growdon JH. PET Radioligands Reveal the Basis of Dementia in Parkinsons Disease and Dementia with Lewy Bodies. Neuro-degenerative Diseases. 2016;16(1-2):118-24. PubMed PMID:26655867; PubMed Central PMCID: PMC4838335.

Greve DN, Salat DH, Bowen SL, Izquierdo-Garcia D, Schultz AP, Catana C, Becker JA, Svarer C, Knudsen GM, Sperling RA, Johnson KA. Different partial volume correction methods lead to different conclusions: An (18)F-FDG-PET study of aging. NeuroImage.2016 May 15;132:334-43. PubMed PMID: 26915497; PubMed Central PMCID: PMC4851886.

Gurol ME, Becker JA, Fotiadis P, Riley G, Schwab K, Johnson KA, Greenberg SM. Florbetapir-PET to diagnose cerebral amyloid angiopathy: A prospective study. Neurology. 2016 November 8;87(19):2043-2049. PubMed PMID: 27605173; PubMed Central PMCID: PMC5109947.

Hanseeuw BJ, Schultz AP, Betensky RA, Sperling RA, Johnson KA. Decreased hippocampal metabolism in high-amyloid mild cognitive impairment. Alzheimer’s Dementia. The Journal of the Alzheimer’s Association. 2016 December;12(12):1288-1296. PubMed PMID: 27421609; PubMed Central PMCID: PMC5148703.

Jack CR Jr, Bennett DA, Blennow K, Carrillo MC, Feldman HH, Frisoni GB, Hampel H, Jagust WJ, Johnson KA, Knopman DS, Petersen RC, Scheltens P, Sperling RA, Dubois B. A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers. Neurology. 2016 August 2;87(5):539-47. PubMed PMID: 27371494; PubMed Central PMCID: PMC4970664.

Johnson KA, Schultz A, Betensky RA, Becker JA, Sepulcre J, Rentz D, Mormino E, Chhatwal J, Amariglio R, Papp K, Marshall G, Albers M, Mauro S, Pepin L, Alverio J, Judge K, Philiossaint M, Shoup T, Yokell D, Dickerson B, Gomez-Isla T, Hyman B, Vasdev N, Sperling R. Tau positron emission tomographic imaging in aging and early Alzheimer disease. Annals of Neurology. 2016 January;79(1):110-9. PubMed PMID: 26505746; PubMed Central PMCID: PMC4738026.

Mormino EC, Papp KV, Rentz DM, Schultz AP, LaPoint M, Amariglio R, Hanseeuw B, Marshall GA, Hedden T, Johnson KA, Sperling RA. Heterogeneity in Suspected Non- Alzheimer Disease Pathophysiology Among Clinically Normal Older Individuals. JAMA Neurology. 2016 October 1;73(10):1185-1191. PubMed PMID: 27548655; PubMed Central PMCID: PMC5266522.

Mormino EC, Sperling RA, Holmes AJ, Buckner RL, De Jager PL, Smoller JW, Sabuncu MR. Polygenic risk of Alzheimer disease is associated with early- and late-life processes. Neurology. 2016 August 2;87(5):481-8. PubMed PMID: 27385740; PubMed Central PMCID: PMC4970660.

Papp KV, Mormino EC, Amariglio RE, Munro C, Dagley A, Schultz AP, Johnson KA, Sperling RA, Rentz DM. Biomarker validation of a decline in semantic processing in preclinical Alzheimer’s Disease. Neuropsychology. 2016 July;30(5):624-30. PubMed PMID: 26595826; PubMed Central PMCID: PMC4877295.

Rentz DM, Dekhtyar M, Sherman J, Burnham S, Blacker D, Aghjayan SL, Papp KV, Amariglio RE, Schembri A, Chenhall T, Maruff P, Aisen P, Hyman BT, Sperling RA. The Feasibility of At-Home iPad Cognitive Testing for Use in Clinical Trials. The Journal of Prevention of Alzheimer’s Disease. 2016 March;3(1):8-12. PubMed PMID:26998469; PubMed Central PMCID: PMC4795477.

Rieckmann A, Hedden T, Younger AP, Sperling RA, Johnson KA, Buckner RL. Dopamine transporter availability in clinically normal aging is associated with individual differences in white matter integrity. Human Brain Mapping. 2016 Feb;37(2):621-31. PubMed PMID: 26542307; PubMed Central PMCID: PMC4729206.

Rieckmann A, Van Dijk KR, Sperling RA, Johnson KA, Buckner RL, Hedden T. Accelerated decline in white matter integrity in clinically normal individuals at risk for Alzheimer’s Disease. Neurobiology of Aging. 2016 June; 42:177-88. PubMed PMID: 27143434; PubMed Central PMCID: PMC4857135.

Sepulcre J, Schultz AP, Sabuncu M, Gomez-Isla T, Chhatwal J, Becker A, Sperling R, Johnson KA. In Vivo Tau, Amyloid, and Gray Matter Profiles in the Aging Brain. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience. 2016 July13;36(28):7364-74. PubMed PMID: 27413148; PubMed Central PMCID: PMC4945661.

Zhang X, Mormino EC, Sun N, Sperling RA, Sabuncu MR, Yeo BT. Bayesian model reveals latent atrophy factors with dissociable cognitive trajectories in Alzheimer’s disease. Proceedings of the National Academy of Sciences of the United States of America. 2016 October 18;113(42):E6535-E6544. PubMed PMID: 27702899; PubMed Central PMCID: PMC5081632.

2015

Amariglio RE, Mormino EC, Pietras AC, Marshall GA, Vannini P, Johnson KA, Sperling RA, Rentz DM. Subjective cognitive concerns, amyloid-β, and neurodegeneration in clinically normal elderly. Neurology. 2015 Jul 7;85(1):56-62. PubMed PMID: 26048028; PubMed Central PMCID: PMC4501939.

Auriel E, Westover MB, Bianchi MT, Reijmer Y, Martinez-Ramirez S, Ni J, Van Etten E, Frosch MP, Fotiadis P, Schwab K, Vashkevich A, Boulouis G, Younger AP, Johnson KA, Sperling RA, Hedden T, Gurol ME, Viswanathan A, Greenberg SM. Estimating Total Cerebral Microinfarct Burden From Diffusion-Weighted Imaging. Stroke. 2015 Aug;46(8):2129-35. PubMed PMID: 26159796; PubMed Central PMCID: PMC4519384.

Chan G, White CC, Winn PA, Cimpean M, Replogle JM, Glick LR, Cuerdon NE, Ryan KJ, Johnson KA, Schneider JA, Bennett DA, Chibnik LB, Sperling RA, Bradshaw EM, DeJager PL. CD33 modulates TREM2: convergence of Alzheimer loci. Nat Neuroscience. 2015 Nov;18(11):1556-8. PubMed PMID: 26414614; PubMed Central PMCID: PMC4682915.

Donovan NJ, Hsu DC, Dagley AS, Schultz AP, Amariglio RE, Mormino EC, Okereke OI, Rentz DM, Johnson KA, Sperling RA, Marshall GA. Depressive Symptoms and Biomarkers of Alzheimer’s Disease in Cognitively Normal Older Adults. J Alzheimer’s Disease. 2015;46(1):63-73. PubMed PMID: 25697700; PubMed Central PMCID: PMC4544638.

Gidicsin CM, Maye JE, Locascio JJ, Pepin LC, Philiossaint M, Becker JA, Younger AP, Dekhtyar M, Schultz AP, Amariglio RE, Marshall GA, Rentz DM, Hedden T, Sperling RA, Johnson KA. Cognitive activity relates to cognitive performance but not to Alzheimer disease biomarkers. Neurology. 2015 Jul 7;85(1):48-55. PubMed PMID: 26062627; PubMed Central PMCID: PMC4501938.

Growdon ME, Schultz AP, Dagley AS, Amariglio RE, Hedden T, Rentz DM, Johnson KA, Sperling RA, Albers MW, Marshall GA. Odor identification and Alzheimer disease biomarkers in clinically normal elderly. Neurology. 2015 May 26;84(21):2153-60. PubMed PMID: 25934852; PubMed Central PMCID: PMC4451046.

Malishkevich A, Marshall GA, Schultz AP, Sperling RA, Aharon-Peretz J, Gozes I. Blood-Borne Activity-Dependent Neuroprotective Protein (ADNP) is Correlated with Premorbid Intelligence, Clinical Stage, and Alzheimer’s Disease Biomarkers. J Alzheimers Disease. 2015 Nov 30;50(1):249-60. PubMed PMID: 26639975; PubMed Central PMCID: PMC4712084.

Marquié M, Normandin MD, Vanderburg CR, Costantino IM, Bien EA, Rycyna LG, Klunk WE, Mathis CA, Ikonomovic MD, Debnath ML, Vasdev N, Dickerson BC, Gomperts SN, Growdon JH, Johnson KA, Frosch MP, Hyman BT, Gómez-Isla T. Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue. Annals of Neurology. 2015 November;78(5):787-800. PubMed PMID: 26344059; PubMed Central PMCID: PMC4900162.

Marshall GA, Dekhtyar M, Bruno JM, Jethwani K, Amariglio RE, Johnson KA, Sperling RA, Rentz DM. The Harvard Automated Phone Task: new performance-based activities of daily living tests for early Alzheimer’s disease. J Prev Alzheimers Disease. 2015Dec;2(4):242-253. PubMed PMID: 26665121; PubMed Central PMCID: PMC4671513.

Papp KV, Amariglio RE, Mormino EC, Hedden T, Dekhytar M, Johnson KA, Sperling RA, Rentz DM. Free and cued memory in relation to biomarker-defined abnormalities in clinically normal older adults and those at risk for Alzheimer’s disease. Neuropsychologia. 2015 July;73:169-75. PubMed PMID: 26002757; PubMed Central PMCID: PMC4479270.

Rabin LA, Smart CM, Crane PK, Amariglio RE, Berman LM, Boada M, Buckley RF, Chételat G, Dubois B, Ellis KA, Gifford KA, Jefferson AL, Jessen F, Katz MJ, Lipton RB, Luck T, Maruff P, Mielke MM, Molinuevo JL, Naeem F, Perrotin A, Petersen RC, Rami L, Reisberg B, Rentz DM, Riedel-Heller SG, Risacher SL, Rodriguez O, Sachdev PS, Saykin AJ, Slavin MJ, Snitz BE, Sperling RA, Tandetnik C, van der Flier WM, Wagner M, Wolfsgruber S, Sikkes SA. Subjective Cognitive Decline in Older Adults: An Overview of Self-Report Measures Used Across 19 International Research Studies. J Alzheimers Disease. 2015 Sep 24;48 Suppl1:S63-86. PubMed PMID: 26402085; PubMed Central PMCID: PMC4617342.

Reijmer YD, Schultz AP, Leemans A, O’Sullivan MJ, Gurol ME, Sperling R, Greenberg SM, Viswanathan A, Hedden T. Decoupling of structural and functional brain connectivity in older adults with white matter hyperintensities. Neuroimage. 2015 Aug 15;117:222-9. PubMed PMID: 26025290; PubMed Central PMCID: PMC4511724.

Replogle JM, Chan G, White CC, Raj T, Winn PA, Evans DA, Sperling RA, Chibnik LB, Bradshaw EM, Schneider JA, Bennett DA, De Jager PL. A TREM1 variant alters the accumulation of Alzheimer-related amyloid pathology. Ann Neurol. 2015 Mar;77(3):469-77. PubMed PMID: 25545807; PubMed Central PMCID: PMC4461024.

Shaw EE, Schultz AP, Sperling RA, Hedden T. Functional Connectivity in Multiple Cortical Networks Is Associated with Performance Across Cognitive Domains in Older Adults. Brain Connect. 2015 Oct;5(8):505-16. PubMed PMID: 25827242; PubMed Central PMCID: PMC4601675.

Sperling RA, Amariglio RE, Marshall GA, Rentz DM. Establishing Clinical Relevance in Preclinical Alzheimer’s Disease. J Prev Alzheimers Disease. 2015 Jun;2(2):85-87. PubMed PMID: 26247003; PubMed Central PMCID: PMC4523117.

Toledo JB, Zetterberg H, van Harten AC, Glodzik L, Martinez-Lage P, Bocchio-Chiavetto L, Rami L, Hansson O, Sperling R, Engelborghs S, Osorio RS, Vanderstichele H, Vandijck M, Hampel H, Teipl S, Moghekar A, Albert M, Hu WT, Monge Argilés JA, Gorostidi A, Teunissen CE, De Deyn PP, Hyman BT, Molinuevo JL, Frisoni GB, Linazasoro G, de Leon MJ, van der Flier WM, Scheltens P, Blennow K, Shaw LM, Trojanowski JQ, Alzheimer’s Disease Neuroimaging Initiative. Alzheimer’s disease cerebrospinal fluid biomarker in cognitively normal subjects. Brain. 2015 Sep;138(Pt9):2701-15. PubMed PMID: 26220940; PubMed Central PMCID: PMC4643624.

2014

Schultz, A. P., Chhatwal, J. P., Huijbers, W., Hedden, T., Van Dijk, K. R., McLaren, D. G., … & Sperling, R. A. (2014). Template based rotation: a method for functional connectivity analysis with a priori templates. Neuroimage, 102, 620-636.

Sperling, R. A., Rentz, D. M., Johnson, K. A., Karlawish, J., Donohue, M., Salmon, D. P., & Aisen, P. (2014). The A4 study: stopping AD before symptoms begin?. Science translational medicine, 6(228), 228fs13-228fs13. 
Serrano-Pozo A, Qian J, Monsell SE, Blacker D, Gómez-Isla T, Betensky RA, Growdon JH, Johnson K, Frosch MP, Sperling RA, Hyman BT (2014). Mild to Moderate Alzheimer Dementia with Insufficient Neuropathological Changes. Annals of Neurology, PMID: 24585367
 
Huijbers W, Mormino E, Wigman S, Ward A, Vannini P, McLaren D, Becker J, Schultz A, Hedden T, Johnson K, and Sperling R (2014). Amyloid deposition is linked to aberrant entorhinal activity among cognitively normal older adults. Journal of Neuroscience, 34(15), 5200-10.
 
Papp, K. V., Amariglio, R. E., Dekhtyar, M., Roy, K., Wigman, S., Bamfo, R., … & Rentz, D. M. (2014). Development of a psychometrically equivalent short form of the face–name associative memory exam for use along the early alzheimer’s disease trajectory. The Clinical Neuropsychologist, 28(5), 771-785.

Mormino, E. C., Betensky, R. A., Hedden, T., Schultz, A. P., Ward, A., Huijbers, W., … & Alzheimer’s Disease Neuroimaging Initiative. (2014). Amyloid and APOE ε4 interact to influence short-term decline in preclinical Alzheimer disease. Neurology, 82(20), 1760-1767. 

2013

Bradshaw, E. M., Chibnik, L. B., Keenan, B. T., Ottoboni, L., Raj, T., Tang, A., … & Morris, M. C. (2013). CD33 Alzheimer’s disease locus: altered monocyte function and amyloid biology. Nature neuroscience, 16(7), 848.

Gomperts SN, Johnson KA, Growdon J (2013). Beyond the limits of detection: failure of PiB imaging to capture true Aβ burden. Movement Disorders, 28(3), 407.

Gomperts, S. N., Locascio, J. J., Rentz, D., Santarlasci, A., Marquie, M., Johnson, K. A., & Growdon, J. H. (2013). Amyloid is linked to cognitive decline in patients with Parkinson disease without dementia. Neurology, 80(1), 85-91.
 
Hedden, T., Oh, H., Younger, A. P., & Patel, T. A. (2013). Meta-analysis of amyloid-cognition relations in cognitively normal older adults. Neurology, 80(14), 1341-1348.

Huijbers, W., Schultz, A. P., Vannini, P., McLaren, D. G., Wigman, S. E., Ward, A. M., … & Sperling, R. A. (2013). The encoding/retrieval flip: interactions between memory performance and memory stage and relationship to intrinsic cortical networks. Journal of cognitive neuroscience, 25(7), 1163-1179.

Johnson, K. A., Minoshima, S., Bohnen, N. I., Donohoe, K. J., Foster, N. L., Herscovitch, P., … & Hedrick, S. (2013). Appropriate use criteria for amyloid PET: a report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer’s Association. Journal of Nuclear Medicine, 54(3), 476-490.

Johnson, K. A., Sperling, R. A., Gidicsin, C. M., Carmasin, J. S., Maye, J. E., Coleman, R. E., … & Doraiswamy, P. M. (2013). Florbetapir (F18-AV-45) PET to assess amyloid burden in Alzheimer’s disease dementia, mild cognitive impairment, and normal aging. Alzheimer’s & Dementia, 9(5), S72-S83.

Li, S., Jin, M., Zhang, D., Yang, T., Koeglsperger, T., Fu, H., & Selkoe, D. J. (2013). Environmental novelty activates β2-adrenergic signaling to prevent the impairment of hippocampal LTP by Aβ oligomers. Neuron, 77(5), 929-941. 

Marshall, G. A., Donovan, N. J., Lorius, N., Gidicsin, C. M., Maye, J., Pepin, L. C., … & Johnson, K. A. (2013). Apathy is associated with increased amyloid burden in mild cognitive impairment. The Journal of neuropsychiatry and clinical neurosciences, 25(4), 302-307.

Perez-Nievas, B. G., Stein, T. D., Tai, H. C., Dols-Icardo, O., Scotton, T. C., Barroeta-Espar, I., … & Serrano-Pozo, A. (2013). Dissecting phenotypic traits linked to human resilience to Alzheimer’s pathology. Brain, 136(8), 2510-2526.

Sepulcre, J., Sabuncu, M. R., Becker, A., Sperling, R., & Johnson, K. A. (2013). In vivo characterization of the early states of the amyloid-beta network. Brain, 136(7), 2239-2252. 

 Sperling, R. A., Johnson, K. A., Doraiswamy, P. M., Reiman, E. M., Fleisher, A. S., Sabbagh, M. N., … & Flitter, M. (2013). Amyloid deposition detected with florbetapir F 18 (18F-AV-45) is related to lower episodic memory performance in clinically normal older individuals. Neurobiology of aging, 34(3), 822-831.

Ward, A. M., McLaren, D. G., Schultz, A. P., Chhatwal, J., Boot, B. P., Hedden, T., & Sperling, R. A. (2013). Daytime sleepiness is associated with decreased default mode network connectivity in both young and cognitively intact elderly subjects. Sleep, 36(11), 1609-1615.
 
Ward, A. M., Schultz, A. P., Huijbers, W., Van Dijk, K. R., Hedden, T., & Sperling, R. A. (2014). The parahippocampal gyrus links the default‐mode cortical network with the medial temporal lobe memory system. Human brain mapping, 35(3), 1061-1073.

2012

Amariglio, R. E., Becker, J. A., Carmasin, J., Wadsworth, L. P., Lorius, N., Sullivan, C., … & Johnson, K. A. (2012). Subjective cognitive complaints and amyloid burden in cognitively normal older individuals. Neuropsychologia, 50(12), 2880-2886.

Amariglio, R. E., Frishe, K., Olson, L. E., Wadsworth, L. P., Lorius, N., Sperling, R. A., & Rentz, D. M. (2012). Validation of the Face Name Associative Memory Exam in cognitively normal older individuals. Journal of clinical and experimental neuropsychology, 34(6), 580-587.

Chhatwal, J. P., & Sperling, R. A. (2012). Functional MRI of mnemonic networks across the spectrum of normal aging, mild cognitive impairment, and Alzheimer’s disease. Journal of Alzheimer’s Disease, 31(s3), S155-S167.

Desikan, R. S., McEvoy, L. K., Thompson, W. K., Holland, D., Brewer, J. B., Aisen, P. S., … & Alzheimer’s Disease Neuroimaging Initiative. (2012). Amyloid-β–associated clinical decline occurs only in the presence of elevated p-tau. Archives of neurology, 69(6), 709-713.

Doraiswamy PM, Sperling RA, Coleman RE, Johnson KA, Reiman EM, Davis MD, Grundman M, Sabbagh MN, Sadowsky CH, Fleisher AS, Carpenter A, Clark CM, Joshi AD, Mintun MA, Skovronsky DM, Pontecorvo MJ; AV45-A11 Study Group. Amyloid-β assessed by florbetapir F 18 PET and 18-month cognitive decline: a multicenter study. Neurology, 79(16),1636-44.

Fleisher, A. S., Chen, K., Liu, X., Ayutyanont, N., Roontiva, A., Thiyyagura, P., … & Sperling, R. A. (2013). Apolipoprotein E ε4 and age effects on florbetapir positron emission tomography in healthy aging and Alzheimer disease. Neurobiology of aging, 34(1), 1-12.

Gomperts, S. N., Locascio, J. J., Marquie, M., Santarlasci, A. L., Rentz, D. M., Maye, J., … & Growdon, J. H. (2012). Brain amyloid and cognition in Lewy body diseases. Movement Disorders, 27(8), 965-973.

Gurol, M. E., Viswanathan, A., Gidicsin, C., Hedden, T., Martinez-Ramirez, S., Dumas, A., … & Becker, A. (2013). Cerebral amyloid angiopathy burden associated with leukoaraiosis: a positron emission tomography/magnetic resonance imaging study. Annals of neurology, 73(4), 529-536.

Huijbers, W., Vannini, P., Sperling, R. A., Pennartz, C. M., Cabeza, R., & Daselaar, S. M. (2012). Explaining the encoding/retrieval flip: memory-related deactivations and activations in the posteromedial cortex. Neuropsychologia, 50(14), 3764-3774.

Hedden, T., Van Dijk, K. R., Shire, E. H., Sperling, R. A., Johnson, K. A., & Buckner, R. L. (2011). Failure to modulate attentional control in advanced aging linked to white matter pathology. Cerebral Cortex, 22(5), 1038-1051.

Hedden, T., Mormino, E. C., Amariglio, R. E., Younger, A. P., Schultz, A. P., Becker, J. A., … & Rentz, D. M. (2012). Cognitive profile of amyloid burden and white matter hyperintensities in cognitively normal older adults. Journal of Neuroscience, 32(46), 16233-16242.

Nordberg A, Petersen RC, Reiman EM, Selkoe DJ, Sperling RA, Van Laere K, Weiner MW, Drzezga A. (2012). Aβ Imaging: feasible, pertinent, and vital to progress in Alzheimer’s disease. European Journal of Nuclear Medicine and Molecular Imaging, 39(2),209-19.

Sabuncu, M. R., Buckner, R. L., Smoller, J. W., Lee, P. H., Fischl, B., Sperling, R. A., & Alzheimer’s Disease Neuroimaging Initiative. (2011). The association between a polygenic Alzheimer score and cortical thickness in clinically normal subjects. Cerebral cortex, 22(11), 2653-2661.
 
Sepulcre, J., Sabuncu, M. R., Yeo, T. B., Liu, H., & Johnson, K. A. (2012). Stepwise connectivity of the modal cortex reveals the multimodal organization of the human brain. Journal of Neuroscience, 32(31), 10649-10661.
 
Townsend, M. K., Okereke, O. I., Xia, W., Yang, T., Selkoe, D. J., & Grodstein, F. (2012). The relation between insulin, insulin-related factors, and plasma amyloid beta peptide levels at mid-life in a population-based study. Alzheimer disease and associated disorders, 26(1), 50.

Vannini, P., Hedden, T., Becker, J. A., Sullivan, C., Putcha, D., Rentz, D., … & Sperling, R. A. (2012). Age and amyloid-related alterations in default network habituation to stimulus repetition. Neurobiology of aging, 33(7), 1237-1252.

Vannini, P., Hedden, T., Huijbers, W., Ward, A., Johnson, K. A., & Sperling, R. A. (2012). The ups and downs of the posteromedial cortex: age-and amyloid-related functional alterations of the encoding/retrieval flip in cognitively normal older adults. Cerebral Cortex, 23(6), 1317-1328.

Vannini, P., Hedden, T., Sullivan, C., & Sperling, R. A. (2013). Differential functional response in the posteromedial cortices and hippocampus to stimulus repetition during successful memory encoding. Human brain mapping, 34(7), 1568-1578.

Villemagne VL, Klunk WE, Mathis CA, Rowe CC, Brooks DJ, Hyman BT, Ikonomovic MD, Ishii K, Jack CR, Jagust WJ, Johnson KA, Koeppe RA, Lowe VJ, Masters CL, Montine TJ, Morris JC, Yang, T., Hong, S., O’Malley, T., Sperling, R. A., Walsh, D. M., & Selkoe, D. J. (2013). New ELISAs with high specificity for soluble oligomers of amyloid β-protein detect natural Aβ oligomers in human brain but not CSF. Alzheimer’s & Dementia, 9(2), 99-112.

2011

Amariglio, R. E., Townsend, M. K., Grodstein, F., Sperling, R. A., & Rentz, D. M. (2011). Specific subjective memory complaints in older persons may indicate poor cognitive function. Journal of the American Geriatrics Society, 59(9), 1612-1617.

Atri, A., O’brien, J. L., Sreenivasan, A., Rastegar, S., Salisbury, S., DeLuca, A. N., … & Sperling, R. A. (2011). Test-retest reliability of memory task functional magnetic resonance imaging in Alzheimer disease clinical trials. Archives of neurology, 68(5), 599-606.

Becker, J. A., Hedden, T., Carmasin, J., Maye, J., Rentz, D. M., Putcha, D., … & Marks, D. (2011). Amyloid‐β associated cortical thinning in clinically normal elderly. Annals of neurology, 69(6), 1032-1042.

Dickerson, B. C., Stoub, T. R., Shah, R. C., Sperling, R. A., Killiany, R. J., Albert, M. S., … & Blacker, D. (2011). Alzheimer-signature MRI biomarker predicts AD dementia in cognitively normal adults. Neurology, 76(16), 1395-1402.
  
Drzezga, A., Becker, J. A., Van Dijk, K. R., Sreenivasan, A., Talukdar, T., Sullivan, C., … & Johnson, K. A. (2011). Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden. Brain, 134(6), 1635-1646.
 
Freir, D. B., Fedriani, R., Scully, D., Smith, I. M., Selkoe, D. J., Walsh, D. M., & Regan, C. M. (2011). Aβ oligomers inhibit synapse remodelling necessary for memory consolidation. Neurobiology of aging, 32(12), 2211-2218.

Hong, S., Quintero-Monzon, O., Ostaszewski, B. L., Podlisny, D. R., Cavanaugh, W. T., Yang, T., … & Selkoe, D. J. (2011). Dynamic analysis of amyloid β-protein in behaving mice reveals opposing changes in ISF versus parenchymal Aβ during age-related plaque formation. Journal of Neuroscience, 31(44), 15861-15869.

Jack Jr, C. R., Albert, M. S., Knopman, D. S., McKhann, G. M., Sperling, R. A., Carrillo, M. C., … & Phelps, C. H. (2011). Introduction to the recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimer’s & Dementia, 7(3), 257-262.
 
Jin, M., Shepardson, N., Yang, T., Chen, G., Walsh, D., & Selkoe, D. J. (2011). Soluble amyloid β-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration. Proceedings of the National Academy of Sciences, 108(14), 5819-5824.
 
Li, S., Jin, M., Koeglsperger, T., Shepardson, N. E., Shankar, G. M., & Selkoe, D. J. (2011). Soluble Aβ oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors. Journal of Neuroscience, 31(18), 6627-6638.
  
Marshall, G. A., Olson, L. E., Frey, M. T., Maye, J., Becker, J. A., Rentz, D. M., … & Alzheimer’s Disease Neuroimaging Initiative. (2011). Instrumental activities of daily living impairment is associated with increased amyloid burden. Dementia and geriatric cognitive disorders, 31(6), 443-450.

Mattsson, N., Andreasson, U., Persson, S., Arai, H., Batish, S. D., Bernardini, S., … & Coart, E. (2011). The Alzheimer’s Association external quality control program for cerebrospinal fluid biomarkers. Alzheimer’s & Dementia, 7(4), 386-395.

Pihlajamäki, M., O’Keefe, K., O’Brien, J., Blacker, D., & Sperling, R. A. (2011). Failure of repetition suppression and memory encoding in aging and Alzheimer’s disease. Brain imaging and behavior, 5(1), 36-44.

Putcha, D., Brickhouse, M., O’Keefe, K., Sullivan, C., Rentz, D., Marshall, G., … & Sperling, R. (2011). Hippocampal hyperactivation associated with cortical thinning in Alzheimer’s disease signature regions in non-demented elderly adults. Journal of Neuroscience, 31(48), 17680-17688.
 
Putcha, D., O’keefe, K., LaViolette, P., O’brien, J., Greve, D., Rentz, D. M., … & Sperling, R. (2011). Reliability of functional magnetic resonance imaging associative encoding memory paradigms in non‐demented elderly adults. Human brain mapping, 32(12), 2027-2044.

Rentz, D. M., Amariglio, R. E., Becker, J. A., Frey, M., Olson, L. E., Frishe, K., … & Sperling, R. A. (2011). Face-name associative memory performance is related to amyloid burden in normal elderly. Neuropsychologia, 49(9), 2776-2783.
 
Sperling, R. A., Aisen, P. S., Beckett, L. A., Bennett, D. A., Craft, S., Fagan, A. M., … & Park, D. C. (2011). Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimer’s & dementia, 7(3), 280-292.

Vannini, P., O’brien, J., O’keefe, K., Pihlajamäki, M., Laviolette, P., & Sperling, R. A. (2010). What goes down must come up: role of the posteromedial cortices in encoding and retrieval. Cerebral Cortex, 21(1), 22-34.

Wang, J., & Chang, C. I. (2006). Independent component analysis-based dimensionality reduction with applications in hyperspectral image analysis. IEEE transactions on geoscience and remote sensing, 44(6), 1586-1600.

2010

Rentz, D. M., Locascio, J. J., Becker, J. A., Moran, E. K., Eng, E., Buckner, R. L., … & Johnson, K. A. (2010). Cognition, reserve, and amyloid deposition in normal aging. Annals of neurology, 67(3), 353-364.

Sperling, R. A., Dickerson, B. C., Pihlajamaki, M., Vannini, P., LaViolette, P. S., Vitolo, O. V., … & Johnson, K. A. (2010). Functional alterations in memory networks in early Alzheimer’s disease. Neuromolecular medicine, 12(1), 27-43.
 
Wang, L., LaViolette, P., O’Keefe, K., Putcha, D., Bakkour, A., Van Dijk, K. R., … & Sperling, R. A. (2010). Intrinsic connectivity between the hippocampus and posteromedial cortex predicts memory performance in cognitively intact older individuals. Neuroimage, 51(2), 910-917.
 
Wang, L., Negreira, A., LaViolette, P., Bakkour, A., Sperling, R. A., & Dickerson, B. C. (2010). Intrinsic interhemispheric hippocampal functional connectivity predicts individual differences in memory performance ability. Hippocampus, 20(3), 345-351.

2009

Buckner, R. L., Sepulcre, J., Talukdar, T., Krienen, F. M., Liu, H., Hedden, T., … & Johnson, K. A. (2009). Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer’s disease. Journal of neuroscience, 29(6), 1860-1873.
 
Sperling, R. A., LaViolette, P. S., O’Keefe, K., O’Brien, J., Rentz, D. M., Pihlajamaki, M., … & Buckner, R. L. (2009). Amyloid deposition is associated with impaired default network function in older persons without dementia. Neuron, 63(2), 178-188.
 
Hedden, T., Van Dijk, K. R., Becker, J. A., Mehta, A., Sperling, R. A., Johnson, K. A., & Buckner, R. L. (2009). Disruption of functional connectivity in clinically normal older adults harboring amyloid burden. Journal of Neuroscience, 29(40), 12686-12694.